butyl 4-(4-((S)-1-((S)-6-(2-hydroxy-2-methylpropyl)-2-oxo-6-phenyl-1,3-oxazinan-3-yl)ethyl)phenyl)-2,2-dimethylbut-3-ynoate

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Chemical Name:butyl 4-(4-((S)-1-((S)-6-(2-hydroxy-2-methylpropyl)-2-oxo-6-phenyl-1,3-oxazinan-3-yl)ethyl)phenyl)-2,2-dimethylbut-3-ynoate
CAS No.:1259034-40-6
Molecular Formula:C₃₂H₄₁NO₅
Molecular Weight:519.681
Hs Code.:

Synonyms:butyl 4-(4-((S)-1-((S)-6-(2-hydroxy-2-methylpropyl)-2-oxo-6-phenyl-1,3-oxazinan-3-yl)ethyl)phenyl)-2,2-dimethylbut-3-ynoate

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Chemical Property of butyl 4-(4-((S)-1-((S)-6-(2-hydroxy-2-methylpropyl)-2-oxo-6-phenyl-1,3-oxazinan-3-yl)ethyl)phenyl)-2,2-dimethylbut-3-ynoate

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Technology Process of butyl 4-(4-((S)-1-((S)-6-(2-hydroxy-2-methylpropyl)-2-oxo-6-phenyl-1,3-oxazinan-3-yl)ethyl)phenyl)-2,2-dimethylbut-3-ynoate

There total 9 articles about butyl 4-(4-((S)-1-((S)-6-(2-hydroxy-2-methylpropyl)-2-oxo-6-phenyl-1,3-oxazinan-3-yl)ethyl)phenyl)-2,2-dimethylbut-3-ynoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.0%

: 1050187-24-0
n-butyl 2,2-dimethyl-3-butynoate

: 1110641-70-7
(S)-3-((S)-1-(4-bromophenyl)ethyl)-6-(2-hydroxy-2-methylpropyl)-6-phenyl-1,3-oxazinan-2-one

: 1259034-40-6
butyl 4-(4-((S)-1-((S)-6-(2-hydroxy-2-methylpropyl)-2-oxo-6-phenyl-1,3-oxazinan-3-yl)ethyl)phenyl)-2,2-dimethylbut-3-ynoate

Guidance literature:: With copper(l) iodide; diethylamine; triethylamine; palladium dichloride; at 100 ℃; for 2.16667h; Irradiation;

Reference yield:

: 27298-97-1
(S)-1-(4-bromophenyl)ethylamine

: 1259034-40-6
butyl 4-(4-((S)-1-((S)-6-(2-hydroxy-2-methylpropyl)-2-oxo-6-phenyl-1,3-oxazinan-3-yl)ethyl)phenyl)-2,2-dimethylbut-3-ynoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydrogencarbonate / dichloromethane; water / 2 - 3 °C

2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / Reflux

3.1: copper(l) chloride; oxygen / palladium dichloride / N,N-dimethyl-formamide; water / 20 °C

4.1: tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

4.2: Cooling with ice

5.1: diethylamine; triethylamine; copper(l) iodide / palladium dichloride / 2.17 h / 100 °C / Irradiation

With copper(l) iodide; oxygen; sodium hydrogencarbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; diethylamine; triethylamine; copper(l) chloride; palladium dichloride; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 936-59-4
3-chloropropiophenone

: 1259034-40-6
butyl 4-(4-((S)-1-((S)-6-(2-hydroxy-2-methylpropyl)-2-oxo-6-phenyl-1,3-oxazinan-3-yl)ethyl)phenyl)-2,2-dimethylbut-3-ynoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: zinc; ammonium chloride / water; tetrahydrofuran / 1 h / Reflux

2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / Reflux

3.1: copper(l) chloride; oxygen / palladium dichloride / N,N-dimethyl-formamide; water / 20 °C

4.1: tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

4.2: Cooling with ice

5.1: diethylamine; triethylamine; copper(l) iodide / palladium dichloride / 2.17 h / 100 °C / Irradiation

With copper(l) iodide; oxygen; ammonium chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; diethylamine; triethylamine; copper(l) chloride; zinc; palladium dichloride; In tetrahydrofuran; water; N,N-dimethyl-formamide;