4-(4-((S)-1-((S)-6-(2-hydroxy-2-methylpropyl)-2-oxo-6-phenyl-1,3-oxazinan-3-yl)ethyl)phenyl)-2,2-dimethylbut-3-ynoic acid

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Chemical Name:4-(4-((S)-1-((S)-6-(2-hydroxy-2-methylpropyl)-2-oxo-6-phenyl-1,3-oxazinan-3-yl)ethyl)phenyl)-2,2-dimethylbut-3-ynoic acid
CAS No.:1259034-39-3
Molecular Formula:C₂₈H₃₃NO₅
Molecular Weight:463.574
Hs Code.:

Synonyms:4-(4-((S)-1-((S)-6-(2-hydroxy-2-methylpropyl)-2-oxo-6-phenyl-1,3-oxazinan-3-yl)ethyl)phenyl)-2,2-dimethylbut-3-ynoic acid

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Chemical Property of 4-(4-((S)-1-((S)-6-(2-hydroxy-2-methylpropyl)-2-oxo-6-phenyl-1,3-oxazinan-3-yl)ethyl)phenyl)-2,2-dimethylbut-3-ynoic acid

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Technology Process of 4-(4-((S)-1-((S)-6-(2-hydroxy-2-methylpropyl)-2-oxo-6-phenyl-1,3-oxazinan-3-yl)ethyl)phenyl)-2,2-dimethylbut-3-ynoic acid

There total 11 articles about 4-(4-((S)-1-((S)-6-(2-hydroxy-2-methylpropyl)-2-oxo-6-phenyl-1,3-oxazinan-3-yl)ethyl)phenyl)-2,2-dimethylbut-3-ynoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1259034-40-6
butyl 4-(4-((S)-1-((S)-6-(2-hydroxy-2-methylpropyl)-2-oxo-6-phenyl-1,3-oxazinan-3-yl)ethyl)phenyl)-2,2-dimethylbut-3-ynoate

: 1259034-39-3
4-(4-((S)-1-((S)-6-(2-hydroxy-2-methylpropyl)-2-oxo-6-phenyl-1,3-oxazinan-3-yl)ethyl)phenyl)-2,2-dimethylbut-3-ynoic acid

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; methanol; water; at 20 ℃; for 24h;

Reference yield:

: 27298-97-1
(S)-1-(4-bromophenyl)ethylamine

: 1259034-39-3
4-(4-((S)-1-((S)-6-(2-hydroxy-2-methylpropyl)-2-oxo-6-phenyl-1,3-oxazinan-3-yl)ethyl)phenyl)-2,2-dimethylbut-3-ynoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydrogencarbonate / dichloromethane; water / 2 - 3 °C

2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / Reflux

3.1: copper(l) chloride; oxygen / palladium dichloride / N,N-dimethyl-formamide; water / 20 °C

4.1: tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

4.2: Cooling with ice

5.1: diethylamine; triethylamine; copper(l) iodide / palladium dichloride / 2.17 h / 100 °C / Irradiation

6.1: lithium hydroxide / water; tetrahydrofuran; methanol / 24 h / 20 °C

With copper(l) iodide; oxygen; sodium hydrogencarbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; diethylamine; triethylamine; copper(l) chloride; lithium hydroxide; palladium dichloride; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 936-59-4
3-chloropropiophenone

: 1259034-39-3
4-(4-((S)-1-((S)-6-(2-hydroxy-2-methylpropyl)-2-oxo-6-phenyl-1,3-oxazinan-3-yl)ethyl)phenyl)-2,2-dimethylbut-3-ynoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: zinc; ammonium chloride / water; tetrahydrofuran / 1 h / Reflux

2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / Reflux

3.1: copper(l) chloride; oxygen / palladium dichloride / N,N-dimethyl-formamide; water / 20 °C

4.1: tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

4.2: Cooling with ice

5.1: diethylamine; triethylamine; copper(l) iodide / palladium dichloride / 2.17 h / 100 °C / Irradiation

6.1: lithium hydroxide / water; tetrahydrofuran; methanol / 24 h / 20 °C

With copper(l) iodide; oxygen; ammonium chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; diethylamine; triethylamine; copper(l) chloride; lithium hydroxide; zinc; palladium dichloride; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;