4-(4-((S)-1-((S)-6-(2-hydroxy-2-methylpropyl)-2-oxo-6-phenyl-1,3-oxazinan-3-yl)ethyl)phenyl)-N,N,2,2-tetramethylbut-3-ynamide

Base Information

Chemical Name:4-(4-((S)-1-((S)-6-(2-hydroxy-2-methylpropyl)-2-oxo-6-phenyl-1,3-oxazinan-3-yl)ethyl)phenyl)-N,N,2,2-tetramethylbut-3-ynamide
CAS No.:1259034-41-7
Molecular Formula:C₃₀H₃₈N₂O₄
Molecular Weight:490.643
Hs Code.:

Synonyms:4-(4-((S)-1-((S)-6-(2-hydroxy-2-methylpropyl)-2-oxo-6-phenyl-1,3-oxazinan-3-yl)ethyl)phenyl)-N,N,2,2-tetramethylbut-3-ynamide

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Chemical Property of 4-(4-((S)-1-((S)-6-(2-hydroxy-2-methylpropyl)-2-oxo-6-phenyl-1,3-oxazinan-3-yl)ethyl)phenyl)-N,N,2,2-tetramethylbut-3-ynamide

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Technology Process of 4-(4-((S)-1-((S)-6-(2-hydroxy-2-methylpropyl)-2-oxo-6-phenyl-1,3-oxazinan-3-yl)ethyl)phenyl)-N,N,2,2-tetramethylbut-3-ynamide

There total 12 articles about 4-(4-((S)-1-((S)-6-(2-hydroxy-2-methylpropyl)-2-oxo-6-phenyl-1,3-oxazinan-3-yl)ethyl)phenyl)-N,N,2,2-tetramethylbut-3-ynamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.0%

: 1259034-39-3
4-(4-((S)-1-((S)-6-(2-hydroxy-2-methylpropyl)-2-oxo-6-phenyl-1,3-oxazinan-3-yl)ethyl)phenyl)-2,2-dimethylbut-3-ynoic acid

: 124-40-3
dimethyl amine

: 1259034-41-7
4-(4-((S)-1-((S)-6-(2-hydroxy-2-methylpropyl)-2-oxo-6-phenyl-1,3-oxazinan-3-yl)ethyl)phenyl)-N,N,2,2-tetramethylbut-3-ynamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; dichloromethane; at 20 ℃;

Reference yield:

: 27298-97-1
(S)-1-(4-bromophenyl)ethylamine

: 1259034-41-7
4-(4-((S)-1-((S)-6-(2-hydroxy-2-methylpropyl)-2-oxo-6-phenyl-1,3-oxazinan-3-yl)ethyl)phenyl)-N,N,2,2-tetramethylbut-3-ynamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydrogencarbonate / dichloromethane; water / 2 - 3 °C

2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / Reflux

3.1: copper(l) chloride; oxygen / palladium dichloride / N,N-dimethyl-formamide; water / 20 °C

4.1: tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

4.2: Cooling with ice

5.1: diethylamine; triethylamine; copper(l) iodide / palladium dichloride / 2.17 h / 100 °C / Irradiation

6.1: lithium hydroxide / water; tetrahydrofuran; methanol / 24 h / 20 °C

7.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane; tetrahydrofuran / 20 °C

With copper(l) iodide; oxygen; sodium hydrogencarbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; diethylamine; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; copper(l) chloride; lithium hydroxide; palladium dichloride; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 936-59-4
3-chloropropiophenone

: 1259034-41-7
4-(4-((S)-1-((S)-6-(2-hydroxy-2-methylpropyl)-2-oxo-6-phenyl-1,3-oxazinan-3-yl)ethyl)phenyl)-N,N,2,2-tetramethylbut-3-ynamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: zinc; ammonium chloride / water; tetrahydrofuran / 1 h / Reflux

2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / Reflux

3.1: copper(l) chloride; oxygen / palladium dichloride / N,N-dimethyl-formamide; water / 20 °C

4.1: tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

4.2: Cooling with ice

5.1: diethylamine; triethylamine; copper(l) iodide / palladium dichloride / 2.17 h / 100 °C / Irradiation

6.1: lithium hydroxide / water; tetrahydrofuran; methanol / 24 h / 20 °C

7.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane; tetrahydrofuran / 20 °C

With copper(l) iodide; oxygen; ammonium chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; diethylamine; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; copper(l) chloride; lithium hydroxide; zinc; palladium dichloride; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;