(4S,4aS,8aR)-octahydro-isoquinoline-2,4-dicarboxylic acid 2-tert-butyl ester

Base Information

Chemical Name:(4S,4aS,8aR)-octahydro-isoquinoline-2,4-dicarboxylic acid 2-tert-butyl ester
CAS No.:362611-65-2
Molecular Formula:C₁₅H₂₅NO₄
Molecular Weight:283.368
Hs Code.:

Synonyms:(4S,4aS,8aR)-octahydro-isoquinoline-2,4-dicarboxylic acid 2-tert-butyl ester

Suppliers and Price of (4S,4aS,8aR)-octahydro-isoquinoline-2,4-dicarboxylic acid 2-tert-butyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4S,4aS,8aR)-octahydro-isoquinoline-2,4-dicarboxylic acid 2-tert-butyl ester

Chemical Property:

Purity/Quality:

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Technology Process of (4S,4aS,8aR)-octahydro-isoquinoline-2,4-dicarboxylic acid 2-tert-butyl ester

There total 3 articles about (4S,4aS,8aR)-octahydro-isoquinoline-2,4-dicarboxylic acid 2-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 646518-37-8
(4S,4aS,8aR)-Octahydro-isoquinoline-2,4-dicarboxylic acid 2-tert-butyl ester 4-ethyl ester

: 362611-65-2
(4S,4aS,8aR)-octahydro-isoquinoline-2,4-dicarboxylic acid 2-tert-butyl ester

Guidance literature:: With lithium hydroxide;
DOI:10.1016/j.bmcl.2010.01.063

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 362611-65-2
(4S,4aS,8aR)-octahydro-isoquinoline-2,4-dicarboxylic acid 2-tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: ethanol / 2 h / 20 °C

2: 154.3 g / LiOH / ethanol / 72 h / 20 °C

With lithium hydroxide; In ethanol;
DOI:10.1016/j.tetasy.2003.07.024

Reference yield:

: 362611-63-0
(4S,4aS,8aR)-decahydro-isoquinoline-4-carboxylic acid ethyl ester

: 362611-65-2
(4S,4aS,8aR)-octahydro-isoquinoline-2,4-dicarboxylic acid 2-tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: ethanol / 2 h / 20 °C

2: 154.3 g / LiOH / ethanol / 72 h / 20 °C

With lithium hydroxide; In ethanol;
DOI:10.1016/j.tetasy.2003.07.024