7-chloro-5-(2-fluorophenyl)-2,3-dihydro-1H-1,4-benzodiazepine-2-N'-hydroxy-N,N-dimethylcarboximidamide 4-oxide

Base Information

Chemical Name:7-chloro-5-(2-fluorophenyl)-2,3-dihydro-1H-1,4-benzodiazepine-2-N'-hydroxy-N,N-dimethylcarboximidamide 4-oxide
CAS No.:76488-25-0
Molecular Formula:C₁₈H₁₈ClFN₄O₂
Molecular Weight:376.818
Hs Code.:

Synonyms:7-chloro-5-(2-fluorophenyl)-2,3-dihydro-1H-1,4-benzodiazepine-2-N'-hydroxy-N,N-dimethylcarboximidamide 4-oxide

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Chemical Property of 7-chloro-5-(2-fluorophenyl)-2,3-dihydro-1H-1,4-benzodiazepine-2-N'-hydroxy-N,N-dimethylcarboximidamide 4-oxide

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Technology Process of 7-chloro-5-(2-fluorophenyl)-2,3-dihydro-1H-1,4-benzodiazepine-2-N'-hydroxy-N,N-dimethylcarboximidamide 4-oxide

There total 3 articles about 7-chloro-5-(2-fluorophenyl)-2,3-dihydro-1H-1,4-benzodiazepine-2-N'-hydroxy-N,N-dimethylcarboximidamide 4-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 76488-13-6
7-chloro-5-(2-fluorophenyl)-3H-1,4-benzodiazepine-2-N'-hydroxy-N-dimethylcarboximidamide 4-oxide

: 76488-25-0
7-chloro-5-(2-fluorophenyl)-2,3-dihydro-1H-1,4-benzodiazepine-2-N'-hydroxy-N,N-dimethylcarboximidamide 4-oxide

Guidance literature:: With sodium tetrahydroborate; In ethanol; for 3h; Ambient temperature;
DOI:10.1002/jhet.5570200313

Reference yield:

: 76488-36-3
7-chloro-5-(2-fluorophenyl)-N-hydroxy-alpha-nitro-3H-1,4-benzodiazepine-2-methanimine 4-oxide

: 76488-25-0
7-chloro-5-(2-fluorophenyl)-2,3-dihydro-1H-1,4-benzodiazepine-2-N'-hydroxy-N,N-dimethylcarboximidamide 4-oxide

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / tetrahydrofuran / Ambient temperature

2: 66 percent / NaBH₄ / ethanol / 3 h / Ambient temperature

With sodium tetrahydroborate; In tetrahydrofuran; ethanol;
DOI:10.1002/jhet.5570200313

Reference yield:

: 60656-76-0
7-chloro-5-(2-fluorophenyl)-2-nitromethylene-2H-1,3-dihydro-1,4-benzodiazepine 4-oxide

: 76488-25-0
7-chloro-5-(2-fluorophenyl)-2,3-dihydro-1H-1,4-benzodiazepine-2-N'-hydroxy-N,N-dimethylcarboximidamide 4-oxide

Guidance literature:: Multi-step reaction with 3 steps

1: 79 percent / NaNO₂ / acetic acid / 1) 70 deg C, 10 min.; 2) room temp., 0.5 h

2: 80 percent / tetrahydrofuran / Ambient temperature

3: 66 percent / NaBH₄ / ethanol / 3 h / Ambient temperature

With sodium tetrahydroborate; sodium nitrite; In tetrahydrofuran; ethanol; acetic acid;
DOI:10.1002/jhet.5570200313