(S)-1-(4-methylbenzyl)-3-(2-pyridin-4-yl-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4-yl)propylamine

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Chemical Name:(S)-1-(4-methylbenzyl)-3-(2-pyridin-4-yl-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4-yl)propylamine
CAS No.:1438880-78-4
Molecular Formula:C₂₅H₂₇N₅S
Molecular Weight:429.589
Hs Code.:

Synonyms:(S)-1-(4-methylbenzyl)-3-(2-pyridin-4-yl-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4-yl)propylamine

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Chemical Property of (S)-1-(4-methylbenzyl)-3-(2-pyridin-4-yl-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4-yl)propylamine

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Technology Process of (S)-1-(4-methylbenzyl)-3-(2-pyridin-4-yl-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4-yl)propylamine

There total 6 articles about (S)-1-(4-methylbenzyl)-3-(2-pyridin-4-yl-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4-yl)propylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1438887-05-8
2,4,6-triisopropylbenzenesulfonic acid 2-pyridin-4-yl-5,6,7,8-tetrahydro-benzo[4,5]thieno[2,3-d]pyrimidin-4-yl ester

: [(S)-2-amino-1-(4-methylbenzyl)ethyl]carbamic acid tert-butyl ester

: 1438880-78-4
(S)-1-(4-methylbenzyl)-3-(2-pyridin-4-yl-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4-yl)propylamine

Guidance literature:: 2,4,6-triisopropylbenzenesulfonic acid 2-pyridin-4-yl-5,6,7,8-tetrahydro-benzo[4,5]thieno[2,3-d]pyrimidin-4-yl ester; [(S)-2-amino-1-(4-methylbenzyl)ethyl]carbamic acid tert-butyl ester; With triethylamine; In N,N-dimethyl acetamide; at 20 ℃; for 2h;

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 886758-87-8
((S)-1-carbamoyl-2-p-tolylethyl)carbamic acid tert-butyl ester

: 1438880-78-4
(S)-1-(4-methylbenzyl)-3-(2-pyridin-4-yl-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4-yl)propylamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: borane-THF / tetrahydrofuran / 20 °C

1.2: 2 h / 20 °C

2.1: triethylamine / N,N-dimethyl acetamide / 2 h / 20 °C

2.2: 1 h / 20 °C

With borane-THF; triethylamine; In tetrahydrofuran; N,N-dimethyl acetamide;

Reference yield:

: 80102-27-8,110762-12-4,80102-26-7
(2S)-3-(4-methylphenyl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid

: 1438880-78-4
(S)-1-(4-methylbenzyl)-3-(2-pyridin-4-yl-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4-yl)propylamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine; di-tert-butyl dicarbonate; ammonium carbonate / 1,4-dioxane / 4 h / 20 °C

2.1: borane-THF / tetrahydrofuran / 20 °C

2.2: 2 h / 20 °C

3.1: triethylamine / N,N-dimethyl acetamide / 2 h / 20 °C

3.2: 1 h / 20 °C

With pyridine; borane-THF; di-tert-butyl dicarbonate; ammonium carbonate; triethylamine; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl acetamide;