2-(Dicyclohexylphosphino)biphenyl

Base Information

• Chemical Name: 2-(Dicyclohexylphosphino)biphenyl
• CAS No.: 247940-06-3
• Molecular Formula: C24H31P
• Molecular Weight: 350.484
• Hs Code.: 29310099
• European Community (EC) Number: 480-030-2,607-439-2
• DSSTox Substance ID: DTXSID60370170
• Nikkaji Number: J1.200.103G,J3.476.307K
• Wikidata: Q72468698
• Mol file: 247940-06-3.mol

Synonyms:2-(Dicyclohexylphosphino)biphenyl;247940-06-3;CyJohnPhos;[1,1'-BIPHENYL]-2-YLDICYCLOHEXYLPHOSPHINE;Dicyclohexyl-(2-phenylphenyl)phosphane;Cyclohexyl JohnPhos;(2-Biphenyl)dicyclohexylphosphine;biphenyl-2-yldicyclohexylphosphine;(2-Biphenylyl)dicyclohexylphosphine;PHOSPHINE, [1,1'-BIPHENYL]-2-YLDICYCLOHEXYL-;o-(dicyclohexylphosphino)biphenyl;MFCD01862441;{[1,1'-biphenyl]-2-yl}dicyclohexylphosphane;2-[dicyclohexylphosphino]biphenyl;dicyclohexyl(2-phenylphenyl)phosphane;2-Dicyclohexylphosphino-biphenyl;C24H31P;2-(dicyclohexylphosphino)-biphenyl;CyJohnPhos, 97%;dicyclohexylphosphinobiphenyl;dicyclohexylphosphino biphenyl;dicyclohexylphosphino-biphenyl;(dicyclohexylphosphino)biphenyl;2-dicyclohexylphosphinobiphenyl;SCHEMBL133189;biphenylyl dicyclohexylphosphine;(dicyclohexylphosphino)-biphenyl;2(dicyclohexylphosphino)biphenyl;2-dicyclohexylphosphino biphenyl;2-(dicyclohexylphospino)biphenyl;2-(Dicydohexylphosphino)biphenyl;2-dicyclohexylphosphanyl-biphenyl;bipheny-2yl-dicyclohexylphosphine;2-(dicyclohexyl)phosphinobiphenyl;2-(dicylcohexylphosphino)biphenyl;2-dicyclohexylphosphino(biphenyl);biphen-2-yl-dicyclohexylphosphine;biphenyl-2-yldicyclohexylphosphane;DTXSID60370170;2-(dicyclohexylphosphanyl)biphenyl;bipheny-2-yl-dicyclohexylphosphine;LCSNDSFWVKMJCT-UHFFFAOYSA-N;(2-biphenyl) dicyclohexylphosphine;(2-biphenyl)dicyclohexyl phosphine;(2-Biphenyl)dicyclohexyl-phosphine;2-(di-cyclohexylphosphino)biphenyl;2-(dicyclohexyl phosphino)biphenyl;2-(dicyclohexyl-phosphino)biphenyl;2-(dicyclohexylphosphino) biphenyl;2-(Dicyclohexylphosphino)biphenyl?;2-biphenylyl(dicyclohexyl)phosphane;biphenyl-2-yl-dicyclohexylphosphane;biphenyl-2-yl-dicyclohexylphosphine;2-(di-cyclohexylphosphino) biphenyl;2-(dicyclohexyl phosphino) biphenyl;2-(dicyclohexyl-phosphino)-biphenyl;BCP04344;(2-biphenylyl) dicyclohexylphosphine;biphenyl-2-yl(dicyclohexyl)phosphane;biphenyl-2-yl(dicyclohexyl)phosphine;biphenyl-2-yl-dicyclohexyl-phosphane;Biphenyl-2-yl-dicyclohexyl-phosphine;dicyclohexyl(2-phenylphenyl)phosphine;(biphenyl-2-yl)dicyclohexyl-phosphine;4-Iodobenzothiophene-2-carboxylicacid;biphenyl-2-yl(dicyclohexyl) phosphane;biphenyl-2-yl(dicyclohexyl) phosphine;AKOS007929928;(aR)-2-(Dicyclohexylphosphino)biphenyl;AC-4976;CS-W002849;GC10123;GS-3511;2-(DICYLOHEXYLPHOSPHINO)BIPHENYL;2-(dicyclohexylphosphino)-1,1'-biphenyl;BP-11312;SY008900;1,1'-biphenyl-2-yl(dicyclohexyl)phosphine;AM20060929;D3388;FT-0647535;A25272;EN300-305200;J-506351;Y-200005

Chemical Property of 2-(Dicyclohexylphosphino)biphenyl

Chemical Property:

• Appearance/Colour: white to light yellow crystal powder
• Vapor Pressure: 1.27E-09mmHg at 25°C
• Melting Point: 102-106 °C(lit.)
• Boiling Point: 499.5 °C at 760 mmHg
• Flash Point: 271.7 °C
• PSA: 13.59000
• LogP: 7.12620
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Sensitive.: Air Sensitive
• Solubility.: soluble in Toluene
• XLogP3: 6.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 0
• Rotatable Bond Count: 4
• Exact Mass: 350.216337987
• Heavy Atom Count: 25
• Complexity: 356

Purity/Quality:

98% ^*data from raw suppliers

2-(Dicyclohexylphosphino)biphenyl ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 36/37/38-22
• Safety Statements: 36/37/39-26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCC(CC1)P(C2CCCCC2)C3=CC=CC=C3C4=CC=CC=C4
• Uses: Ligand employed in an extremely general method for the Pd-catalyzed synthesis of aromaticamines using aryl chlorides, bromides and triflates. suzuki reaction 2-(Dicyclohexylphosphino)biphenyl is used as a catalyst for Suzuki coupling reactions.

Technology Process of 2-(Dicyclohexylphosphino)biphenyl

There total 13 articles about 2-(Dicyclohexylphosphino)biphenyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

methanol (67-56-1) + (2-biphenyl)dicyclohexylphosphane-borane(1:1) (1186392-99-3) → Trimethyl borate (121-43-7,63156-11-6) + CyJohnPhos (247940-06-3)

Guidance literature:

In toluene; at 100 ℃; Inert atmosphere;

DOI:10.1016/j.tet.2009.05.063

Reference yield: 93.0%

([1,1’-biphenyl]-2-yl)dicyclohexylphosphine oxide → CyJohnPhos (247940-06-3)

Guidance literature:

With 1,3-diphenyl-disiloxane; In toluene; at 110 ℃; chemoselective reaction; Sealed tube;

DOI:10.1002/chem.201703875

Reference yield: 81.0%

2-Bromobiphenyl (2052-07-5) + dicyclohexylphosphane (829-84-5) → CyJohnPhos (247940-06-3)

Guidance literature:

With bis(η3-allyl-μ-chloropalladium(II)); potassium hydroxide; In water; at 100 ℃; Inert atmosphere;

DOI:10.1055/s-0036-1590926

upstream raw materials:

2-Bromobiphenyl

chlorodicyclohexylphosphane

biphenyl-2-yl trifluoromethanesulfonate

dicyclohexylphosphane

Downstream raw materials:

4-(4-methoxy-3-nitrophenyl)morpholine

2-methyl-2-(4-{2-[5-methyl-2-(2'-trifluoromethyl-biphenyl-4-yl)-oxazol-4-yl]-ethoxy}-phenoxy)propionic acid ethyl ester

2-(4-{2-[2-(2'-fluoro-biphenyl-4-yl)-5-methyloxazol-4-yl]-ethoxy}-phenoxy)-2-methylpropionic acid ethyl ester

2-(4-{2-[2-(2'-methoxy-biphenyl-4-yl)-5-methyloxazol-4-yl]-ethoxy}-phenoxy)-2-methylpropionic acid ethyl ester