2-[(2-chloro-5-methoxypyrimidin-4-yl)amino]-N-methylbenzamide

Base Information

• Chemical Name: 2-[(2-chloro-5-methoxypyrimidin-4-yl)amino]-N-methylbenzamide
• CAS No.: 1042434-82-1
• Molecular Formula: C₁₃H₁₃ClN₄O₂
• Molecular Weight: 292.725
• Mol file: 1042434-82-1.mol

Synonyms:2-[(2-chloro-5-methoxypyrimidin-4-yl)amino]-N-methylbenzamide

Chemical Property of 2-[(2-chloro-5-methoxypyrimidin-4-yl)amino]-N-methylbenzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[(2-chloro-5-methoxypyrimidin-4-yl)amino]-N-methylbenzamide

There total 2 articles about 2-[(2-chloro-5-methoxypyrimidin-4-yl)amino]-N-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

2-Amino-N-methylbenzamid (4141-08-6) + 2,4-dichloro-5-methoxypyrimidine (19646-07-2) → 2-[(2-chloro-5-methoxypyrimidin-4-yl)amino]-N-methylbenzamide (1042434-82-1)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 24h;

DOI:10.1016/j.ejmech.2019.05.048

Reference yield:

2-nitrobenzyl chloride (610-14-0) → 2-[(2-chloro-5-methoxypyrimidin-4-yl)amino]-N-methylbenzamide (1042434-82-1)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydrogencarbonate / acetonitrile / 4 h / Reflux

2: iron; ammonium chloride / water; ethanol / 2 h / Reflux

3: sodium hydride / N,N-dimethyl-formamide / 24 h / 0 - 20 °C

With iron; sodium hydride; sodium hydrogencarbonate; ammonium chloride; In ethanol; water; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1016/j.ejmech.2019.05.048

Reference yield: 59.0%

4-(4-aminobenzoyl)piperazine-1-carboxylic acid tert-butyl ester (350684-49-0) + 2-[(2-chloro-5-methoxypyrimidin-4-yl)amino]-N-methylbenzamide (1042434-82-1) → tert-butyl 4-(4-((5-methoxy-4-((2-(methylcarbamoyl)phenyl)amino)pyrimidin-2-yl)amino)benzoyl)piperazine-1-carboxylate

Guidance literature:

With potassium phosphate; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In N,N-dimethyl-formamide; at 125 ℃; for 22h; Inert atmosphere;

DOI:10.1016/j.ejmech.2019.05.048

upstream raw materials:

2-Amino-N-methylbenzamid

2,4-dichloro-5-methoxypyrimidine

2-nitrobenzyl chloride