methyl 5-(2-amino-3-methoxy-3-oxopropyl)(2-cyanoethylamino)-2-(4-methoxyphenyl)oxazole-4-carboxylate

Base Information

Chemical Name:methyl 5-(2-amino-3-methoxy-3-oxopropyl)(2-cyanoethylamino)-2-(4-methoxyphenyl)oxazole-4-carboxylate
CAS No.:1308790-73-9
Molecular Formula:C₁₉H₂₂N₄O₆
Molecular Weight:402.407
Hs Code.:

Synonyms:methyl 5-(2-amino-3-methoxy-3-oxopropyl)(2-cyanoethylamino)-2-(4-methoxyphenyl)oxazole-4-carboxylate

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Chemical Property of methyl 5-(2-amino-3-methoxy-3-oxopropyl)(2-cyanoethylamino)-2-(4-methoxyphenyl)oxazole-4-carboxylate

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Technology Process of methyl 5-(2-amino-3-methoxy-3-oxopropyl)(2-cyanoethylamino)-2-(4-methoxyphenyl)oxazole-4-carboxylate

There total 5 articles about methyl 5-(2-amino-3-methoxy-3-oxopropyl)(2-cyanoethylamino)-2-(4-methoxyphenyl)oxazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1308790-72-8
methyl 5-((2-(benzyloxycarbonylamino)-3-methoxy-3-oxopropyl)(2-cyanoethyl)amino)-2-(4-methoxyphenyl)oxazole-4-carboxylate

: 1308790-73-9
methyl 5-(2-amino-3-methoxy-3-oxopropyl)(2-cyanoethylamino)-2-(4-methoxyphenyl)oxazole-4-carboxylate

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 3h; under 760.051 Torr;
DOI:10.5012/bkcs.2011.32.3.1041

Reference yield:

: 1308790-66-0
methyl 2-(benzyloxycarbonylamino)-3-(2-cyanoethylamino)propanoate

: 1308790-73-9
methyl 5-(2-amino-3-methoxy-3-oxopropyl)(2-cyanoethylamino)-2-(4-methoxyphenyl)oxazole-4-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: 4-methyl-morpholine / dichloromethane / 14 h / -15 - 20 °C

2: 4-acetamidobenzenesulfonyl azide; triethylamine / benzene / 45 h / 20 °C

3: rhodium (II) octanoate dimer / toluene / 4 h / 80 °C

4: trichlorophosphate / N,N-dimethyl-formamide / 3 h / 60 °C

5: palladium 10% on activated carbon; hydrogen / methanol / 3 h / 20 °C / 760.05 Torr

With 4-methyl-morpholine; rhodium (II) octanoate dimer; palladium 10% on activated carbon; 4-acetamidobenzenesulfonyl azide; hydrogen; triethylamine; trichlorophosphate; In methanol; dichloromethane; N,N-dimethyl-formamide; toluene; benzene;
DOI:10.5012/bkcs.2011.32.3.1041

Reference yield:

: 1308790-67-1
methyl 2-(benzyloxycarbonylamino)-3-(N-(2-cyanoethyl)-3-methoxy-3-oxopropanamido)propanoate

: 1308790-73-9
methyl 5-(2-amino-3-methoxy-3-oxopropyl)(2-cyanoethylamino)-2-(4-methoxyphenyl)oxazole-4-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 4-acetamidobenzenesulfonyl azide; triethylamine / benzene / 45 h / 20 °C

2: rhodium (II) octanoate dimer / toluene / 4 h / 80 °C

3: trichlorophosphate / N,N-dimethyl-formamide / 3 h / 60 °C

4: palladium 10% on activated carbon; hydrogen / methanol / 3 h / 20 °C / 760.05 Torr

With rhodium (II) octanoate dimer; palladium 10% on activated carbon; 4-acetamidobenzenesulfonyl azide; hydrogen; triethylamine; trichlorophosphate; In methanol; N,N-dimethyl-formamide; toluene; benzene;
DOI:10.5012/bkcs.2011.32.3.1041