methyl 3-((2-(benzyloxycarbonylamino)-3-methoxy-3-oxopropyl)(2-cyanoethyl)amino)-2-diazo-3-oxopropanoate

Base Information

Chemical Name:methyl 3-((2-(benzyloxycarbonylamino)-3-methoxy-3-oxopropyl)(2-cyanoethyl)amino)-2-diazo-3-oxopropanoate
CAS No.:1308790-68-2
Molecular Formula:C₁₉H₂₁N₅O₇
Molecular Weight:431.405
Hs Code.:

Synonyms:methyl 3-((2-(benzyloxycarbonylamino)-3-methoxy-3-oxopropyl)(2-cyanoethyl)amino)-2-diazo-3-oxopropanoate

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Chemical Property of methyl 3-((2-(benzyloxycarbonylamino)-3-methoxy-3-oxopropyl)(2-cyanoethyl)amino)-2-diazo-3-oxopropanoate

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Technology Process of methyl 3-((2-(benzyloxycarbonylamino)-3-methoxy-3-oxopropyl)(2-cyanoethyl)amino)-2-diazo-3-oxopropanoate

There total 5 articles about methyl 3-((2-(benzyloxycarbonylamino)-3-methoxy-3-oxopropyl)(2-cyanoethyl)amino)-2-diazo-3-oxopropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1308790-67-1
methyl 2-(benzyloxycarbonylamino)-3-(N-(2-cyanoethyl)-3-methoxy-3-oxopropanamido)propanoate

: 1308790-68-2
methyl 3-((2-(benzyloxycarbonylamino)-3-methoxy-3-oxopropyl)(2-cyanoethyl)amino)-2-diazo-3-oxopropanoate

Guidance literature:: With 4-acetamidobenzenesulfonyl azide; triethylamine; In benzene; at 20 ℃; for 45h;
DOI:10.5012/bkcs.2011.32.3.1041

Reference yield:

: 18635-43-3
2-(S)-benzyloxycarbonylamino-3-aminopropionic acid

: 1308790-68-2
methyl 3-((2-(benzyloxycarbonylamino)-3-methoxy-3-oxopropyl)(2-cyanoethyl)amino)-2-diazo-3-oxopropanoate

Guidance literature:: Multi-step reaction with 4 steps

1: thionyl chloride / 10 h / 0 - 20 °C

2: triethylamine / methanol / Reflux

3: 4-methyl-morpholine / dichloromethane / 14 h / -15 - 20 °C

4: 4-acetamidobenzenesulfonyl azide; triethylamine / benzene / 45 h / 20 °C

With 4-methyl-morpholine; thionyl chloride; 4-acetamidobenzenesulfonyl azide; triethylamine; In methanol; dichloromethane; benzene; 2: Michael addition;
DOI:10.5012/bkcs.2011.32.3.1041

Reference yield:

: 185564-12-9
methyl ester of N-alpha-(CO₂-CH₂-phenyl)-alpha,beta-diaminopropionic acid

: 1308790-68-2
methyl 3-((2-(benzyloxycarbonylamino)-3-methoxy-3-oxopropyl)(2-cyanoethyl)amino)-2-diazo-3-oxopropanoate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / methanol / Reflux

2: 4-methyl-morpholine / dichloromethane / 14 h / -15 - 20 °C

3: 4-acetamidobenzenesulfonyl azide; triethylamine / benzene / 45 h / 20 °C

With 4-methyl-morpholine; 4-acetamidobenzenesulfonyl azide; triethylamine; In methanol; dichloromethane; benzene; 1: Michael addition;
DOI:10.5012/bkcs.2011.32.3.1041