methyl 2-(benzyloxycarbonylamino)-3-(N-(2-cyanoethyl)-3-methoxy-3-oxopropanamido)propanoate

Base Information

Chemical Name:methyl 2-(benzyloxycarbonylamino)-3-(N-(2-cyanoethyl)-3-methoxy-3-oxopropanamido)propanoate
CAS No.:1308790-67-1
Molecular Formula:C₁₉H₂₃N₃O₇
Molecular Weight:405.408
Hs Code.:

Synonyms:methyl 2-(benzyloxycarbonylamino)-3-(N-(2-cyanoethyl)-3-methoxy-3-oxopropanamido)propanoate

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Chemical Property of methyl 2-(benzyloxycarbonylamino)-3-(N-(2-cyanoethyl)-3-methoxy-3-oxopropanamido)propanoate

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Technology Process of methyl 2-(benzyloxycarbonylamino)-3-(N-(2-cyanoethyl)-3-methoxy-3-oxopropanamido)propanoate

There total 4 articles about methyl 2-(benzyloxycarbonylamino)-3-(N-(2-cyanoethyl)-3-methoxy-3-oxopropanamido)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 37517-81-0
3-chloro-3-oxopropanoic acid methyl ester

: 1308790-66-0
methyl 2-(benzyloxycarbonylamino)-3-(2-cyanoethylamino)propanoate

: 1308790-67-1
methyl 2-(benzyloxycarbonylamino)-3-(N-(2-cyanoethyl)-3-methoxy-3-oxopropanamido)propanoate

Guidance literature:: With 4-methyl-morpholine; In dichloromethane; at -15 - 20 ℃; for 14h;
DOI:10.5012/bkcs.2011.32.3.1041

Reference yield:

: 29880-22-6
N-benzyloxy-carbonyl-DL-asparagine

: 1308790-67-1
methyl 2-(benzyloxycarbonylamino)-3-(N-(2-cyanoethyl)-3-methoxy-3-oxopropanamido)propanoate

Guidance literature:: Multi-step reaction with 4 steps

1: [bis(acetoxy)iodo]benzene / water; ethyl acetate; acetonitrile / 16 h / 20 °C

2: thionyl chloride / 10 h / 0 - 20 °C

3: triethylamine / methanol / Reflux

4: 4-methyl-morpholine / dichloromethane / 14 h / -15 - 20 °C

With 4-methyl-morpholine; thionyl chloride; [bis(acetoxy)iodo]benzene; triethylamine; In methanol; dichloromethane; water; ethyl acetate; acetonitrile; 1: Hofmann rearrangement / 3: Michael addition;
DOI:10.5012/bkcs.2011.32.3.1041

Reference yield:

: 185564-12-9
methyl ester of N-alpha-(CO₂-CH₂-phenyl)-alpha,beta-diaminopropionic acid

: 1308790-67-1
methyl 2-(benzyloxycarbonylamino)-3-(N-(2-cyanoethyl)-3-methoxy-3-oxopropanamido)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / methanol / Reflux

2: 4-methyl-morpholine / dichloromethane / 14 h / -15 - 20 °C

With 4-methyl-morpholine; triethylamine; In methanol; dichloromethane; 1: Michael addition;
DOI:10.5012/bkcs.2011.32.3.1041