methyl N-{2-[N-(allyloxycarbonyl)-N-(2-(N-(2-benzyloxycarbonylaminoethyl)-N-(tert-butoxycarbonyl)glycylamino)ethyl)glycylamino]ethyl}-N-[(9H-fluoren-9-yl)methyloxycarbonyl]glycinate

Base Information

Chemical Name:methyl N-{2-[N-(allyloxycarbonyl)-N-(2-(N-(2-benzyloxycarbonylaminoethyl)-N-(tert-butoxycarbonyl)glycylamino)ethyl)glycylamino]ethyl}-N-[(9H-fluoren-9-yl)methyloxycarbonyl]glycinate
CAS No.:1352089-38-3
Molecular Formula:C₄₅H₅₆N₆O₁₂
Molecular Weight:872.973
Hs Code.:

methyl N-{2-[N-(allyloxycarbonyl)-N-(2-(N-(2-benzyloxycarbonylaminoethyl)-N-(tert-butoxycarbonyl)glycylamino)ethyl)glycylamino]ethyl}-N-[(9H-fluoren-9-yl)methyloxycarbonyl]glycinate

Synonyms:methyl N-{2-[N-(allyloxycarbonyl)-N-(2-(N-(2-benzyloxycarbonylaminoethyl)-N-(tert-butoxycarbonyl)glycylamino)ethyl)glycylamino]ethyl}-N-[(9H-fluoren-9-yl)methyloxycarbonyl]glycinate

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Chemical Property of methyl N-{2-[N-(allyloxycarbonyl)-N-(2-(N-(2-benzyloxycarbonylaminoethyl)-N-(tert-butoxycarbonyl)glycylamino)ethyl)glycylamino]ethyl}-N-[(9H-fluoren-9-yl)methyloxycarbonyl]glycinate

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Technology Process of methyl N-{2-[N-(allyloxycarbonyl)-N-(2-(N-(2-benzyloxycarbonylaminoethyl)-N-(tert-butoxycarbonyl)glycylamino)ethyl)glycylamino]ethyl}-N-[(9H-fluoren-9-yl)methyloxycarbonyl]glycinate

There total 9 articles about methyl N-{2-[N-(allyloxycarbonyl)-N-(2-(N-(2-benzyloxycarbonylaminoethyl)-N-(tert-butoxycarbonyl)glycylamino)ethyl)glycylamino]ethyl}-N-[(9H-fluoren-9-yl)methyloxycarbonyl]glycinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: H-Aeg(Alloc)-Aeg(Fmoc)-OMe*TFA

: 70889-83-7
N-(2-benzyloxycarbonylaminoethyl)-N-(tert-butoxycarbonyl)glycine

: 1352089-38-3
methyl N-{2-[N-(allyloxycarbonyl)-N-(2-(N-(2-benzyloxycarbonylaminoethyl)-N-(tert-butoxycarbonyl)glycylamino)ethyl)glycylamino]ethyl}-N-[(9H-fluoren-9-yl)methyloxycarbonyl]glycinate

Guidance literature:: N-(2-benzyloxycarbonylaminoethyl)-N-(tert-butoxycarbonyl)glycine; With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 0.5h; Inert atmosphere;

H-Aeg(Alloc)-Aeg(Fmoc)-OMe*TFA; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;
DOI:10.1002/hlca.201100243

Reference yield:

: 1352089-37-2
methyl N-{2-[N-(2-tert-butoxycarbonylaminoethyl)-N-(prop-2-en-1-yloxycarbonyl)]glycylaminoethyl}-N-[(9H-fluoren-9-yl)methyloxycarbonyl]glycinate

: 1352089-38-3
methyl N-{2-[N-(allyloxycarbonyl)-N-(2-(N-(2-benzyloxycarbonylaminoethyl)-N-(tert-butoxycarbonyl)glycylamino)ethyl)glycylamino]ethyl}-N-[(9H-fluoren-9-yl)methyloxycarbonyl]glycinate

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylsilane / dichloromethane / 3 h / 0 - 20 °C

2.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / Inert atmosphere

2.2: 20 °C / Inert atmosphere

With triethylsilane; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/hlca.201100243

Reference yield:

: 1352089-36-1
methyl N-[(9-H-fluoren-9-yl)methoxycarbonyl]-N-(2-tert-butoxycarbonylaminoethyl)glycinate

: 1352089-38-3
methyl N-{2-[N-(allyloxycarbonyl)-N-(2-(N-(2-benzyloxycarbonylaminoethyl)-N-(tert-butoxycarbonyl)glycylamino)ethyl)glycylamino]ethyl}-N-[(9H-fluoren-9-yl)methyloxycarbonyl]glycinate

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylsilane / dichloromethane / 3 h / 0 - 20 °C

2.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / Inert atmosphere

2.2: 20 °C / Inert atmosphere

3.1: triethylsilane / dichloromethane / 3 h / 0 - 20 °C

4.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / Inert atmosphere

4.2: 20 °C / Inert atmosphere

With triethylsilane; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/hlca.201100243