N-[2-(1,3-Dihudro-1,3-dioxo-2H-isoindolys)]2-hydroxybenzoylamide

Base Information

• Chemical Name: N-[2-(1,3-Dihudro-1,3-dioxo-2H-isoindolys)]2-hydroxybenzoylamide
• CAS No.: 57187-42-5
• Molecular Formula: C15H10N2O4
• Molecular Weight: 282.255
• Mol file: 57187-42-5.mol

Synonyms:N-Salicylamidophthalimide;N-[2-(1,3-Dihudro-1,3-dioxo-2H-isoindolys)]2-hydroxybenzoylamide;

Chemical Property of N-[2-(1,3-Dihudro-1,3-dioxo-2H-isoindolys)]2-hydroxybenzoylamide

Chemical Property:

• PSA: 86.71000
• Density: 1.54 g/cm³
• LogP: 1.66200

Purity/Quality:

98%min ^*data from raw suppliers

N-[2-(1,3-Dihudro-1,3-dioxo-2H-isoindolyS)]2-hydroxybenzoylamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-[2-(1,3-Dihudro-1,3-dioxo-2H-isoindolys)]2-hydroxybenzoylamide

There total 4 articles about N-[2-(1,3-Dihudro-1,3-dioxo-2H-isoindolys)]2-hydroxybenzoylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

phthalic anhydride (85-44-9) + 2-Hydroxybenzoylhydrazine (936-02-7) → N-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-2-hydroxybenzamide (57187-42-5)

Guidance literature:

With acetic acid; at 130 ℃; for 3h; Reflux;

Reference yield:

methyl salicylate (119-36-8,8024-54-2) → N-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-2-hydroxybenzamide (57187-42-5)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine hydrate / methanol / 16 h / Reflux

2: acetic acid / 3 h / 130 °C / Reflux

With hydrazine hydrate; acetic acid; In methanol;

Reference yield:

salicylic acid (69-72-7,25496-36-0,8052-31-1) → N-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-2-hydroxybenzamide (57187-42-5)

Guidance literature:

Multi-step reaction with 3 steps

1: Reflux

2: hydrazine hydrate / methanol / 16 h / Reflux

3: acetic acid / 3 h / 130 °C / Reflux

With hydrazine hydrate; acetic acid; In methanol;

upstream raw materials:

phthalic anhydride

2-Hydroxybenzoylhydrazine

methyl salicylate

salicylic acid

Refernces

• 1、 Gondolova,Ismailova,Fatullaeva,Mejidov. "Co(II), Ni(II), and Cu(II) Complexes of N-(2-Hydroxybenzamido)phthalimide". . p. 546 - 548. Retrieved 2019.
• 2、 Ghareb, Nagat,Elshihawy, Hosam A.,Abdel-Daim, Mohamed M.,Helal, Mohamed A.. "Novel pyrazoles and pyrazolo[1,2-a]pyridazines as selective COX-2 inhibitors; Ultrasound-assisted synthesis, biological evaluation, and DFT calculations". supporting information. p. 2377 - 2383. Retrieved 2017/05/09.