5,8-Dimethoxy-1,2,3,4-tetrhydroisoquinoline-3-carboxylic acid ethyl ester

Base Information

• Chemical Name: 5,8-Dimethoxy-1,2,3,4-tetrhydroisoquinoline-3-carboxylic acid ethyl ester
• CAS No.: 198021-01-1
• Molecular Formula: C₁₄H₁₉NO₄
• Molecular Weight: 265.309
• Hs Code.: 2933499090
• Mol file: 198021-01-1.mol

Synonyms:Ethyl 5,8-dimethoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylate;5,8-DIMETHOXY-1,2,3,4-TETRHYDROISOQUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER;REF DUPL: 5,8-Dimethoxy-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid ethyl ester;3-Isoquinolinecarboxylic acid, 1,2,3,4-tetrahydro-5,8-dimethoxy-, ethyl ester

Chemical Property of 5,8-Dimethoxy-1,2,3,4-tetrhydroisoquinoline-3-carboxylic acid ethyl ester

Chemical Property:

• Vapor Pressure: 3.5E-07mmHg at 25°C
• Refractive Index: 1.515
• Boiling Point: 417.604 °C at 760 mmHg
• Flash Point: 206.359 °C
• PSA: 56.79000
• Density: 1.132 g/cm³
• LogP: 1.61000

Purity/Quality:

97% ^*data from raw suppliers

Ethyl5,8-dimethoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5,8-Dimethoxy-1,2,3,4-tetrhydroisoquinoline-3-carboxylic acid ethyl ester

There total 14 articles about 5,8-Dimethoxy-1,2,3,4-tetrhydroisoquinoline-3-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

ethyl N-diphenylmethylene glycine (69555-14-2) + 1,4-dimethoxy-2,3-bis(bromomethyl)benzene (19164-83-1) → ethyl 5,8-dimethoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylate (198021-01-1)

Guidance literature:

ethyl N-diphenylmethylene glycine; 1,4-dimethoxy-2,3-bis(bromomethyl)benzene; With tetra(n-butyl)ammonium hydrogensulfate; potassium hydroxide; In dichloromethane; water; at 20 ℃; for 0.5h;

With hydrogenchloride; In tetrahydrofuran; water; at 20 ℃; for 0.5h;

DOI:10.1055/s-0033-1340070

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + ethyl 2,5-dimethoxyphenylalanine (603944-28-1) → ethyl 5,8-dimethoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylate (198021-01-1)

Guidance literature:

formaldehyd; ethyl 2,5-dimethoxyphenylalanine; With trifluoroacetic acid; In dichloromethane; water; at 20 ℃; for 5h;

With sodium hydrogencarbonate; In dichloromethane; water;

DOI:10.1016/j.tet.2012.01.005

Reference yield:

ethanol (64-17-5) + methyl 5,8-dimethoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylate (1326317-14-9) → ethyl 5,8-dimethoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylate (198021-01-1)

Guidance literature:

methyl 5,8-dimethoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylate; With lithium hydroxide; In methanol; at 20 ℃; for 5h;

ethanol; With thionyl chloride; In dichloromethane; at 0 ℃; for 4h; Reflux;

DOI:10.1016/j.tet.2012.01.005

upstream raw materials:

1,4-dimethoxy-2,3-bis(bromomethyl)benzene

2-(Benzhydrylidene-amino)-3-(2-bromomethyl-3,6-dimethoxy-phenyl)-propionic acid ethyl ester

formaldehyd

ethyl 2,5-dimethoxyphenylalanine

Downstream raw materials:

7,10-dimethoxy-2-benzyl-2,3,11,11a-tetrahydro-6H-pyrazino[1,2-b]isoquinoline-1,4-dione

2-(4-chlorobenzyl)-7,10-dimethoxy-2,3,11,11a-tetrahydro-6H-pyrazino[1,2-b]isoquinoline-1,4-dione

C₂₂H₂₄N₂O₄

7,10-dimethoxy-2-benzyl-3,4,11,11a-tetrahydro-2H,6H-pyrazino[1,2-b]isoquinolin-1-one