5'-O-(4,4'-Dimethoxytrityl)-N6-benzoyl-2'-deoxyadenosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite

Base Information

Chemical Name:5'-O-(4,4'-Dimethoxytrityl)-N6-benzoyl-2'-deoxyadenosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite
CAS No.:98796-53-3
Molecular Formula:C47H52 N7 O7 P
Molecular Weight:857.946
Hs Code.:29349990
European Community (EC) Number:685-521-7
DSSTox Substance ID:DTXSID501103329
Nikkaji Number:J587.394K
Mol file:98796-53-3.mol

Synonyms:Adenosine,N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-, 3'-[2-cyanoethylbis(1-methylethyl)phosphoramidite] (9CI)

Suppliers and Price of 5'-O-(4,4'-Dimethoxytrityl)-N6-benzoyl-2'-deoxyadenosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
N6-Benzoyl-2’-deoxy-5’-O-DMT-cytidine3’-CEPhosphoramidite
1g
$ 415.00

Sigma-Aldrich
DMT-dA(bz) Phosphoramidite ≥99% (31P-NMR)
500g
$ 4870.00

Sigma-Aldrich
DMT-dA(bz) Phosphoramidite
214.6 g
$ 2620.00

Sigma-Aldrich
DMT-dA(bz) Phosphoramidite configured for MerMade
20x10g
$ 2200.00

Sigma-Aldrich
DMT-dA(bz) Phosphoramidite ≥99% (31P-NMR)
20x40g
$ 17240.00

Sigma-Aldrich
DMT-dA(bz) Phosphoramidite ≥99% (31P-NMR)
1kg
$ 10030.00

Sigma-Aldrich
DMT-dA(bz) Phosphoramidite ≥99% (31P-NMR)
4x30g
$ 1750.00

Sigma-Aldrich
DMT-dA(bz) Phosphoramidite ≥99% (31P-NMR)
6x20g
$ 1410.00

Sigma-Aldrich
DMT-dA(bz) Phosphoramidite ≥99% (31P-NMR)
100g
$ 1100.00

Sigma-Aldrich
DMT-dA(bz) Phosphoramidite ≥99% (31P-NMR)
6x10g
$ 731.00

Total 63 raw suppliers

Chemical Property of 5'-O-(4,4'-Dimethoxytrityl)-N6-benzoyl-2'-deoxyadenosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite

Chemical Property:

Vapor Pressure:0-0Pa at 20-50℃
PKA:7.87±0.43(Predicted)
PSA：168.70000
Density:1.23 at 20℃
LogP:9.12618
Storage Temp.:Store at -20°C
Solubility.:soluble, clear
XLogP3:6.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:12
Rotatable Bond Count:19
Exact Mass:857.36658402
Heavy Atom Count:62
Complexity:1380

Purity/Quality:

99% ^*data from raw suppliers

N6-Benzoyl-2’-deoxy-5’-O-DMT-cytidine3’-CEPhosphoramidite ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)N(C(C)C)P(OCCC#N)OC1CC(OC1COC(C2=CC=CC=C2)(C3=CC=C(C=C3)OC)C4=CC=C(C=C4)OC)N5C=NC6=C(N=CN=C65)NC(=O)C7=CC=CC=C7
Isomeric SMILES:CC(C)N(C(C)C)P(OCCC#N)O[C@H]1C[C@@H](O[C@@H]1COC(C2=CC=CC=C2)(C3=CC=C(C=C3)OC)C4=CC=C(C=C4)OC)N5C=NC6=C(N=CN=C65)NC(=O)C7=CC=CC=C7
Uses N6-Benzoyl-2’-deoxy-5’-O-DMT-cytidine 3’-CE Phosphoramidite is used to prepare antisense oligonucleotides containing conformationally constrained methoxyaminomethylene and aminooxymethylene and aminomethylene bridged nucleoside analogs.

Technology Process of 5'-O-(4,4'-Dimethoxytrityl)-N6-benzoyl-2'-deoxyadenosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite

There total 10 articles about 5'-O-(4,4'-Dimethoxytrityl)-N6-benzoyl-2'-deoxyadenosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 98796-53-3
N₆-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine-3'-O-[O-(2-cyanoethyl)-N,N'-diisopropylphosphoramidite]

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; toluene; for 0.0833333h;

With dmap; In dichloromethane; toluene; for 0.133333h;

Reference yield: 98.0%

: 102691-36-1
N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite

: 64325-78-6
N₆-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine

: 98796-53-3
N₆-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine-3'-O-[O-(2-cyanoethyl)-N,N'-diisopropylphosphoramidite]

Guidance literature:: With chloro-trimethyl-silane; In tetrahydrofuran; for 1h; Ambient temperature;
DOI:10.1039/a701924f

Reference yield: 92.0%

: 124482-92-4,89992-70-1
2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine

: 64325-78-6
N₆-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine

: 98796-53-3
N₆-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine-3'-O-[O-(2-cyanoethyl)-N,N'-diisopropylphosphoramidite]

Guidance literature:: N₆-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine; With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 0.166667h;

2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine; With 1-hexyl-1-methylimidazoliumtris(pentafluoroethyl)trifluorophosphate; for 1.75h;
DOI:10.1039/b905000k