(R)-isopropyl pivaloyloxymethyl 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate

Base Information

Chemical Name:(R)-isopropyl pivaloyloxymethyl 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate
CAS No.:174840-07-4
Molecular Formula:C₂₄H₂₉Cl₂NO₆
Molecular Weight:498.403
Hs Code.:

Synonyms:(R)-isopropyl pivaloyloxymethyl 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate

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Chemical Property of (R)-isopropyl pivaloyloxymethyl 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate

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Technology Process of (R)-isopropyl pivaloyloxymethyl 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate

There total 4 articles about (R)-isopropyl pivaloyloxymethyl 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4-(2,3-Dichloro-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-tert-butoxycarbonylmethyl ester 5-(2,2-dimethyl-propionyloxymethyl) ester

: 174840-07-4
(R)-isopropyl pivaloyloxymethyl 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: lipase AH / cyclohexane / 95 h / Ambient temperature

2: dicyclohexylcarbodiimide, 4-dimethylaminopyridine / tetrahydrofuran / 18 h

With dmap; lipase AH; dicyclohexyl-carbodiimide; In tetrahydrofuran; cyclohexane;
DOI:10.1248/cpb.45.869

Reference yield:

: 4-(2,3-Dichloro-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid bis-(2,2-dimethyl-propionyloxymethyl) ester

: 174840-07-4
(R)-isopropyl pivaloyloxymethyl 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: lipase AH / cyclohexane; H₂O / 312 h / Ambient temperature

2: dicyclohexylcarbodiimide, 4-dimethylaminopyridine / dimethylformamide

With dmap; lipase AH; dicyclohexyl-carbodiimide; In cyclohexane; water; N,N-dimethyl-formamide;