(S)-isopropyl 4-(2,3-dichlorophenyl)-1,4-dihydro-2-hydroxymethyl-3-methoxycarbonyl-6-methyl-5-pyridinecarboxylate

Base Information

Chemical Name:(S)-isopropyl 4-(2,3-dichlorophenyl)-1,4-dihydro-2-hydroxymethyl-3-methoxycarbonyl-6-methyl-5-pyridinecarboxylate
CAS No.:144686-70-4
Molecular Formula:C₁₉H₂₁Cl₂NO₅
Molecular Weight:414.285
Hs Code.:

Synonyms:(S)-isopropyl 4-(2,3-dichlorophenyl)-1,4-dihydro-2-hydroxymethyl-3-methoxycarbonyl-6-methyl-5-pyridinecarboxylate

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Chemical Property of (S)-isopropyl 4-(2,3-dichlorophenyl)-1,4-dihydro-2-hydroxymethyl-3-methoxycarbonyl-6-methyl-5-pyridinecarboxylate

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Technology Process of (S)-isopropyl 4-(2,3-dichlorophenyl)-1,4-dihydro-2-hydroxymethyl-3-methoxycarbonyl-6-methyl-5-pyridinecarboxylate

There total 13 articles about (S)-isopropyl 4-(2,3-dichlorophenyl)-1,4-dihydro-2-hydroxymethyl-3-methoxycarbonyl-6-methyl-5-pyridinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 144732-91-2
(S)-isopropyl 4-acetoxymethyl-4-(2,3-dichlorophenyl)-1,4-dihydro-5-methoxycarbonyl-6-methyl-3-pyridinecarboxylate

: 144686-70-4
(S)-isopropyl 4-(2,3-dichlorophenyl)-1,4-dihydro-2-hydroxymethyl-3-methoxycarbonyl-6-methyl-5-pyridinecarboxylate

Guidance literature:: With ammonia; In methanol; at 0 ℃; for 0.5h;
DOI:10.1248/cpb.45.869

Reference yield:

: (S)-1-(tert-Butyl-dimethyl-silanyl)-2-(tert-butyl-dimethyl-silanyloxymethyl)-4-(2,3-dichloro-phenyl)-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-isopropyl ester 5-methyl ester

: 144686-69-1
(R)-isopropyl 4-(2,3-dichlorophenyl)-1,4-dihydro-2-hydroxymethyl-3-methoxycarbonyl-6-methyl-5-pyridinecarboxylate

: 144686-70-4
(S)-isopropyl 4-(2,3-dichlorophenyl)-1,4-dihydro-2-hydroxymethyl-3-methoxycarbonyl-6-methyl-5-pyridinecarboxylate

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 ℃; for 0.25h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
DOI:10.1248/cpb.45.869

Reference yield:

: 174840-08-5
(S)-isopropyl pivaloyloxymethyl 2-bromomethyl-4-(2,3-dichlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate

: 144686-70-4
(S)-isopropyl 4-(2,3-dichlorophenyl)-1,4-dihydro-2-hydroxymethyl-3-methoxycarbonyl-6-methyl-5-pyridinecarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: aq. AgNO₃ / acetone / 18 h / Ambient temperature

2: imidazole / dimethylformamide / 5 h / Ambient temperature

3: 5percent NaOH / acetone / 1.5 h

4: diethyl ether; acetone / 0.5 h / 0 °C

5: n-Bu₄NF / tetrahydrofuran / 0.25 h / 0 °C

With 1H-imidazole; sodium hydroxide; tetrabutyl ammonium fluoride; silver nitrate; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide; acetone;
DOI:10.1248/cpb.45.869