1-benzyl-3-[2-(tert-butyldimethylsilanoxy)ethyl]-4-methoxy-1,4,5,6-tetrahydropyridine

Base Information

Chemical Name:1-benzyl-3-[2-(tert-butyldimethylsilanoxy)ethyl]-4-methoxy-1,4,5,6-tetrahydropyridine
CAS No.:412054-27-4
Molecular Formula:C₂₁H₃₅NO₂Si
Molecular Weight:361.6
Hs Code.:

Synonyms:1-benzyl-3-[2-(tert-butyldimethylsilanoxy)ethyl]-4-methoxy-1,4,5,6-tetrahydropyridine

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Chemical Property of 1-benzyl-3-[2-(tert-butyldimethylsilanoxy)ethyl]-4-methoxy-1,4,5,6-tetrahydropyridine

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Technology Process of 1-benzyl-3-[2-(tert-butyldimethylsilanoxy)ethyl]-4-methoxy-1,4,5,6-tetrahydropyridine

There total 5 articles about 1-benzyl-3-[2-(tert-butyldimethylsilanoxy)ethyl]-4-methoxy-1,4,5,6-tetrahydropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 124-41-4
sodium methylate

: 412054-38-7
1-benzyl-3-[2-(tert-butyldimethylsilanoxy)ethyl]-1-oxy-1,2,5,6-tetrahydropyridine

: 412054-27-4
1-benzyl-3-[2-(tert-butyldimethylsilanoxy)ethyl]-4-methoxy-1,4,5,6-tetrahydropyridine

Guidance literature:: 1-benzyl-3-[2-(tert-butyldimethylsilanoxy)ethyl]-1-oxy-1,2,5,6-tetrahydropyridine; With trifluoroacetic anhydride; In dichloromethane; at 0 ℃; for 0.333333h;

sodium methylate; In methanol; dichloromethane; Further stages.;
DOI:10.1021/jo0162033

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 412054-27-4
1-benzyl-3-[2-(tert-butyldimethylsilanoxy)ethyl]-4-methoxy-1,4,5,6-tetrahydropyridine

Guidance literature:: Multi-step reaction with 5 steps

1.1: 97 percent / imidazole / dimethylformamide / 15 h / 20 °C

2.1: 90 percent / toluene / 40 h / 65 °C

3.1: 80 percent / NaBH₄ / methanol / 1.33 h / -78 - 0 °C

4.1: 99 percent / m-CPBA / CH₂Cl₂

5.1: trifluoroacetic anhydride / CH₂Cl₂ / 0.33 h / 0 °C

5.2: 69 percent / methanol; CH₂Cl₂

With 1H-imidazole; sodium tetrahydroborate; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic anhydride; In methanol; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo0162033

Reference yield:

: 146667-81-4
3-(2-ethyl)pyridine

: 412054-27-4
1-benzyl-3-[2-(tert-butyldimethylsilanoxy)ethyl]-4-methoxy-1,4,5,6-tetrahydropyridine

Guidance literature:: Multi-step reaction with 4 steps

1.1: 90 percent / toluene / 40 h / 65 °C

2.1: 80 percent / NaBH₄ / methanol / 1.33 h / -78 - 0 °C

3.1: 99 percent / m-CPBA / CH₂Cl₂

4.1: trifluoroacetic anhydride / CH₂Cl₂ / 0.33 h / 0 °C

4.2: 69 percent / methanol; CH₂Cl₂

With sodium tetrahydroborate; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic anhydride; In methanol; dichloromethane; toluene;
DOI:10.1021/jo0162033