2,6-dimethyl-3,5-bis[di(1-methyl-2-imidazolyl)(3-cyanobenzyloxy)methyl]pyridine

Base Information

• Chemical Name: 2,6-dimethyl-3,5-bis[di(1-methyl-2-imidazolyl)(3-cyanobenzyloxy)methyl]pyridine
• CAS No.: 591770-02-4
• Molecular Formula: C₄₁H₃₉N₁₁O₂
• Molecular Weight: 717.833
• Mol file: 591770-02-4.mol

Synonyms:2,6-dimethyl-3,5-bis[di(1-methyl-2-imidazolyl)(3-cyanobenzyloxy)methyl]pyridine

Chemical Property of 2,6-dimethyl-3,5-bis[di(1-methyl-2-imidazolyl)(3-cyanobenzyloxy)methyl]pyridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,6-dimethyl-3,5-bis[di(1-methyl-2-imidazolyl)(3-cyanobenzyloxy)methyl]pyridine

There total 2 articles about 2,6-dimethyl-3,5-bis[di(1-methyl-2-imidazolyl)(3-cyanobenzyloxy)methyl]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

m-(bromomethyl)benzonitrile (28188-41-2) + 2,6-dihydroxymethyl-3,5-bis[di(1-methyl-2-imidazolyl)hydroxymethyl]pyridine (591770-01-3) → 2,6-dimethyl-3,5-bis[di(1-methyl-2-imidazolyl)(3-cyanobenzyloxy)methyl]pyridine (591770-02-4)

Guidance literature:

2,6-dihydroxymethyl-3,5-bis[di(1-methyl-2-imidazolyl)hydroxymethyl]pyridine; With potassium hydroxide; In dimethyl sulfoxide; at 20 ℃; for 0.166667h;

m-(bromomethyl)benzonitrile; In dimethyl sulfoxide; at 20 ℃; for 5h; Further stages.;

DOI:10.1002/chem.200390082

Reference yield:

dimethyl 2,6-dimethylpyridine-3,5-dicarboxylate (27525-74-2) → 2,6-dimethyl-3,5-bis[di(1-methyl-2-imidazolyl)(3-cyanobenzyloxy)methyl]pyridine (591770-02-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: nBuLi / hexane; tetrahydrofuran / 1 h / -78 °C

1.2: 70 percent / hexane; tetrahydrofuran / -78 - 20 °C

2.1: KOH / dimethylsulfoxide / 0.17 h / 20 °C

2.2: 65 percent / dimethylsulfoxide / 5 h / 20 °C

With potassium hydroxide; n-butyllithium; In tetrahydrofuran; hexane; dimethyl sulfoxide;

DOI:10.1002/chem.200390082

Reference yield: 91.0%

2,6-dimethyl-3,5-bis[di(1-methyl-2-imidazolyl)(3-cyanobenzyloxy)methyl]pyridine (591770-02-4) → 2,6-dimethyl-3,5-bis-[di(1-methyl-2-imidazolyl)(3-carboxybenzyloxy)methyl]pyridine

Guidance literature:

With sodium hydroxide; In isopropyl alcohol; at 130 ℃; for 12h;

DOI:10.1002/chem.200390082

upstream raw materials:

m-(bromomethyl)benzonitrile

2,6-dihydroxymethyl-3,5-bis[di(1-methyl-2-imidazolyl)hydroxymethyl]pyridine

dimethyl 2,6-dimethylpyridine-3,5-dicarboxylate