3-(2R,3R)-1,4-diethoxy-3-hydroxy-1,4-dioxobutan-2-yl 5-ethyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

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Chemical Name:3-(2R,3R)-1,4-diethoxy-3-hydroxy-1,4-dioxobutan-2-yl 5-ethyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
CAS No.:1352187-24-6
Molecular Formula:C₂₅H₂₉Cl₂NO₉
Molecular Weight:558.413
Hs Code.:

Synonyms:3-(2R,3R)-1,4-diethoxy-3-hydroxy-1,4-dioxobutan-2-yl 5-ethyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

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Chemical Property of 3-(2R,3R)-1,4-diethoxy-3-hydroxy-1,4-dioxobutan-2-yl 5-ethyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

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Technology Process of 3-(2R,3R)-1,4-diethoxy-3-hydroxy-1,4-dioxobutan-2-yl 5-ethyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

There total 2 articles about 3-(2R,3R)-1,4-diethoxy-3-hydroxy-1,4-dioxobutan-2-yl 5-ethyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 1352187-25-7
C₃₄H₄₉Cl₂NO₉Si

: 1352187-24-6
3-(2R,3R)-1,4-diethoxy-3-hydroxy-1,4-dioxobutan-2-yl 5-ethyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 0.0833333h; Inert atmosphere;
DOI:10.1016/j.tet.2011.10.025

Reference yield:

: 1352187-21-3
(2R,3R)-diethyl 2-(2-(2,3-dichlorobenzylidene)-3-oxobutanoyloxy)-3-(triisopropylsilyloxy)succinate

: 626-34-6
ethyl 3-aminobut-2-enoate

: 1352187-24-6
3-(2R,3R)-1,4-diethoxy-3-hydroxy-1,4-dioxobutan-2-yl 5-ethyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / 6 h / Reflux

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.08 h / 20 °C / Inert atmosphere

With pyridine; tetrabutyl ammonium fluoride; In tetrahydrofuran; 1: Hantzsch dihydropyridine synthesis;
DOI:10.1016/j.tet.2011.10.025