2-(3-amino-2-cyano-4-nitrophenyl)-2-methyl-3-oxobutyric acid ethyl ester

Base Information

• Chemical Name: 2-(3-amino-2-cyano-4-nitrophenyl)-2-methyl-3-oxobutyric acid ethyl ester
• CAS No.: 333458-30-3
• Molecular Formula: C₁₄H₁₅N₃O₅
• Molecular Weight: 305.29

Synonyms:2-(3-amino-2-cyano-4-nitrophenyl)-2-methyl-3-oxobutyric acid ethyl ester

Chemical Property of 2-(3-amino-2-cyano-4-nitrophenyl)-2-methyl-3-oxobutyric acid ethyl ester

Chemical Property:

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Technology Process of 2-(3-amino-2-cyano-4-nitrophenyl)-2-methyl-3-oxobutyric acid ethyl ester

There total 2 articles about 2-(3-amino-2-cyano-4-nitrophenyl)-2-methyl-3-oxobutyric acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

2-acetylpropanoic acid ethyl ester (609-14-3) + 2-amino-6-chloro-3-nitro-benzonitrile (333459-71-5) → 2-(3-amino-2-cyano-4-nitrophenyl)-2-methyl-3-oxobutyric acid ethyl ester (333458-30-3)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 24h;

DOI:10.1021/jm020446l

Reference yield: 46.0%

2-amino-6-chloro-3-nitro-benzonitrile (333459-71-5) + acetoacetic acid methyl ester (105-45-3) → 2-(3-amino-2-cyano-4-nitrophenyl)-2-methyl-3-oxobutyric acid ethyl ester (333458-30-3)

Guidance literature:

In hydrogenchloride; hexane; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

2-(3-amino-2-cyano-4-nitrophenyl)-2-methyl-3-oxobutyric acid ethyl ester (333458-30-3) → 2-(3,4-diamino-2-cyanophenyl)-2-methyl-3-oxobutyric acid ethyl ester (524695-75-8)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethyl acetate;

DOI:10.1016/S0040-4039(02)01802-6

upstream raw materials:

2-acetylpropanoic acid ethyl ester

2-amino-6-chloro-3-nitro-benzonitrile

acetoacetic acid methyl ester

Downstream raw materials:

2-(3,4-diamino-2-cyanophenyl)-2-methyl-3-oxobutyric acid ethyl ester

2-(2,6-Dichlorophenylamino)-6,7-dimethyl-1,8-dihydro-imidazo[4,5-h]isoquinoline-9-one

2-[4-cyano-2-(2,6-dichloro-phenylamino)-3H-benzoimidazol-5-yl]-2-methyl-3-oxo-butyric acid ethyl ester

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