N⁶,N⁶,2'-O-tribenzoyl-3'-deoxy-5'-O-(monomethoxytrityl)adenosine

Base Information

• Chemical Name: N⁶,N⁶,2'-O-tribenzoyl-3'-deoxy-5'-O-(monomethoxytrityl)adenosine
• CAS No.: 76885-93-3
• Molecular Formula: C₅₁H₄₁N₅O₇
• Molecular Weight: 835.916
• Mol file: 76885-93-3.mol

Synonyms:N⁶,N⁶,2'-O-tribenzoyl-3'-deoxy-5'-O-(monomethoxytrityl)adenosine

Chemical Property of N⁶,N⁶,2'-O-tribenzoyl-3'-deoxy-5'-O-(monomethoxytrityl)adenosine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N⁶,N⁶,2'-O-tribenzoyl-3'-deoxy-5'-O-(monomethoxytrityl)adenosine

There total 3 articles about N⁶,N⁶,2'-O-tribenzoyl-3'-deoxy-5'-O-(monomethoxytrityl)adenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

benzoyl chloride (98-88-4) + N6-benzoyl-3'-deoxy-5'-O-(monomethoxytrityl)adenosine (76885-92-2) → N6,N6,2'-O-tribenzoyl-3'-deoxy-5'-O-(monomethoxytrityl)adenosine (76885-93-3)

Guidance literature:

With pyridine; for 2h; Ambient temperature;

DOI:10.1002/hlca.19870700808

Reference yield:

N-(9-((2R,3R,5S)-3-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide (76902-49-3) → N6,N6,2'-O-tribenzoyl-3'-deoxy-5'-O-(monomethoxytrityl)adenosine (76885-93-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 81 percent / pyridine / methanol / 24 h / Ambient temperature; the more 30 min

2: 92 percent / pyridine / 2 h / Ambient temperature

With pyridine; In methanol;

DOI:10.1002/hlca.19870700808

Reference yield:

(2R,3R,5S)-2-[6-(N-benzoylbenzamido)-9H-purin-9-yl]-5-[(benzoyloxy)methyl]oxolan-3-yl benzoate (66884-45-5) → N6,N6,2'-O-tribenzoyl-3'-deoxy-5'-O-(monomethoxytrityl)adenosine (76885-93-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 84 percent / NaOH (1N) / ethanol; pyridine / 0.75 h / Ambient temperature

2: 81 percent / pyridine / methanol / 24 h / Ambient temperature; the more 30 min

3: 92 percent / pyridine / 2 h / Ambient temperature

With pyridine; sodium hydroxide; In pyridine; methanol; ethanol;

DOI:10.1002/hlca.19870700808

upstream raw materials:

benzoyl chloride

N⁶-benzoyl-3'-deoxy-5'-O-(monomethoxytrityl)adenosine

N-(9-((2R,3R,5S)-3-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide

(2R,3R,5S)-2-[6-(N-benzoylbenzamido)-9H-purin-9-yl]-5-[(benzoyloxy)methyl]oxolan-3-yl benzoate

Downstream raw materials:

N⁶,N⁶,2'-O-tribenzoyl-3'-deoxyadenosine