ethyl 3-(5-(4-bromophenyl)-1-(4-carbamoyl-2-methylphenyl)-1H-pyrrol-2-yl)propanoate

Base Information

Chemical Name:ethyl 3-(5-(4-bromophenyl)-1-(4-carbamoyl-2-methylphenyl)-1H-pyrrol-2-yl)propanoate
CAS No.:1208318-09-5
Molecular Formula:C₂₃H₂₃BrN₂O₃
Molecular Weight:455.351
Hs Code.:

Synonyms:ethyl 3-(5-(4-bromophenyl)-1-(4-carbamoyl-2-methylphenyl)-1H-pyrrol-2-yl)propanoate

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Chemical Property of ethyl 3-(5-(4-bromophenyl)-1-(4-carbamoyl-2-methylphenyl)-1H-pyrrol-2-yl)propanoate

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Technology Process of ethyl 3-(5-(4-bromophenyl)-1-(4-carbamoyl-2-methylphenyl)-1H-pyrrol-2-yl)propanoate

There total 9 articles about ethyl 3-(5-(4-bromophenyl)-1-(4-carbamoyl-2-methylphenyl)-1H-pyrrol-2-yl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 1208318-08-4
ethyl 7-(4-bromophenyl)-4,7-dioxoheptanoate

: 106037-36-9
4-amino-3-methylbenzamide

: 1208318-09-5
ethyl 3-(5-(4-bromophenyl)-1-(4-carbamoyl-2-methylphenyl)-1H-pyrrol-2-yl)propanoate

Guidance literature:: With toluene-4-sulfonic acid; In ethanol; Reflux;

Reference yield:

: 1208318-10-8
3-methyl-4-(1H-pyrrol-1-yl)benzamide

: 1208318-09-5
ethyl 3-(5-(4-bromophenyl)-1-(4-carbamoyl-2-methylphenyl)-1H-pyrrol-2-yl)propanoate

Guidance literature:: Multi-step reaction with 6 steps

1: trichlorophosphate

2: toluene / Reflux

3: palladium 10% on activated carbon; hydrogen / ethanol

4: N-Bromosuccinimide

5: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate

6: dihydrogen peroxide; potassium carbonate / dimethyl sulfoxide / 20 °C

With N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; hydrogen; dihydrogen peroxide; sodium carbonate; potassium carbonate; trichlorophosphate; In ethanol; dimethyl sulfoxide; toluene; 1: Vilsmeier formylation / 2: Wittig reaction / 5: Suzuki coupling;
DOI:10.1021/ml200045s

Reference yield:

: 1208318-11-9
4-(2-formyl-1H-pyrrol-1-yl)-3-methylbenzonitrile

: 1208318-09-5
ethyl 3-(5-(4-bromophenyl)-1-(4-carbamoyl-2-methylphenyl)-1H-pyrrol-2-yl)propanoate

Guidance literature:: Multi-step reaction with 5 steps

1: toluene / Reflux

2: palladium 10% on activated carbon; hydrogen / ethanol

3: N-Bromosuccinimide

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate

5: dihydrogen peroxide; potassium carbonate / dimethyl sulfoxide / 20 °C

With N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; hydrogen; dihydrogen peroxide; sodium carbonate; potassium carbonate; In ethanol; dimethyl sulfoxide; toluene; 1: Wittig reaction / 4: Suzuki coupling;
DOI:10.1021/ml200045s