(2R,3R,4S,5S)-3,4-bis(benzyloxy)-2-[(benzyloxy)methyl]-5-ethynyltetrahydrofuran

Base Information

• Chemical Name: (2R,3R,4S,5S)-3,4-bis(benzyloxy)-2-[(benzyloxy)methyl]-5-ethynyltetrahydrofuran
• CAS No.: 36792-96-8
• Molecular Formula: C₂₈H₂₈O₄
• Molecular Weight: 428.528

Synonyms:(2R,3R,4S,5S)-3,4-bis(benzyloxy)-2-[(benzyloxy)methyl]-5-ethynyltetrahydrofuran

Chemical Property of (2R,3R,4S,5S)-3,4-bis(benzyloxy)-2-[(benzyloxy)methyl]-5-ethynyltetrahydrofuran

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R,3R,4S,5S)-3,4-bis(benzyloxy)-2-[(benzyloxy)methyl]-5-ethynyltetrahydrofuran

There total 9 articles about (2R,3R,4S,5S)-3,4-bis(benzyloxy)-2-[(benzyloxy)methyl]-5-ethynyltetrahydrofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

diethylphosphonooxy-(2,3,5-tri-O-benzyl-β-ribofuranosyl)-acetonitrile → (2R,3R,4S,5S)-3,4-bis(benzyloxy)-2-[(benzyloxy)methyl]-5-ethynyltetrahydrofuran (36792-96-8)

Guidance literature:

With sodium azide; triethylamine hydrochloride; In tetrahydrofuran; for 16h; Reflux;

DOI:10.1021/acs.joc.7b00346

Reference yield: 42.0%

(4S,5R,6R)-4,5,6,7-Tetrakis-benzyloxy-hept-1-yn-3-ol → (2R,3R,4S,5S)-3,4-bis(benzyloxy)-2-[(benzyloxy)methyl]-5-ethynyltetrahydrofuran (36792-96-8) + 2,3,5-tri-O-benzyl-α-D-ribofuranosylethyne (54656-61-0)

Guidance literature:

With p-toluenesulfonyl chloride; In pyridine; Ambient temperature;

DOI:10.1039/P19810002267

Reference yield:

1-trimethylsilylethynyl-5-O-acetyl-2,3-O-isopropylidene-β-D-ribofuranose + benzyl bromide (100-39-0) → (2R,3R,4S,5S)-3,4-bis(benzyloxy)-2-[(benzyloxy)methyl]-5-ethynyltetrahydrofuran (36792-96-8)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃;

DOI:10.1055/s-0036-1588409

upstream raw materials:

(2R,3R,4R)-2,3,4,5-tetrakis(benzyloxy)pentanal

2,5-anhydro-3,4,6-tri-O-benzyl-aldehydo-D-altrohexofuranose

D-Ribose

1,5-O-diacetyl-2,3-O-isopropylidene-D-ribofuranoside

Downstream raw materials:

(1S)-tri-O-benzyl-1-(1H-pyrazol-4-yl)-D-1,4-anhydro-ribitol

3(5)-(2,3,5-tri-O-benzyl-β-D-ribofuranosyl)pyrazole

1-benzyl-4-(2′,3′,5′-tri-O-benzyl-β-D-ribofuranosyl)-1,2,3-triazole

1-benzyl-5-(2,3,5-tri-O-benzyl-β-D-ribofuranosyl)-1,2,3-triazole

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 36792-96-8 (2R,3R,4S,5S)-3,4-bis(benzyloxy)-2-[(benzyloxy)methyl]-5-ethynyltetrahydrofuran

Send

Send

Metric Ton KG G Pound L ML

Send

Send