1-(phenylsulfonamido)-2-{4-[2-(piperidin-4-yl)ethoxy]benzamido}ethylthiophosphonic acid

Base Information

Chemical Name:1-(phenylsulfonamido)-2-{4-[2-(piperidin-4-yl)ethoxy]benzamido}ethylthiophosphonic acid
CAS No.:1354924-66-5
Molecular Formula:C₂₂H₃₀N₃O₆PS₂
Molecular Weight:527.602
Hs Code.:

Synonyms:1-(phenylsulfonamido)-2-{4-[2-(piperidin-4-yl)ethoxy]benzamido}ethylthiophosphonic acid

Suppliers and Price of 1-(phenylsulfonamido)-2-{4-[2-(piperidin-4-yl)ethoxy]benzamido}ethylthiophosphonic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-(phenylsulfonamido)-2-{4-[2-(piperidin-4-yl)ethoxy]benzamido}ethylthiophosphonic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-(phenylsulfonamido)-2-{4-[2-(piperidin-4-yl)ethoxy]benzamido}ethylthiophosphonic acid

There total 8 articles about 1-(phenylsulfonamido)-2-{4-[2-(piperidin-4-yl)ethoxy]benzamido}ethylthiophosphonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1354924-55-2
1-(phenylsulfonamido)-2-{4-[2-(piperidin-4-yl)ethoxy]benzamido}ethylphosphinic acid

: 1354924-66-5
1-(phenylsulfonamido)-2-{4-[2-(piperidin-4-yl)ethoxy]benzamido}ethylthiophosphonic acid

Guidance literature:: With N,O-bis-(trimethylsilyl)-acetamide; sulfur; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1021/jm2013826

Reference yield:

: 622-26-4
4-(2-Hydroxyethyl)piperidine

: 1354924-66-5
1-(phenylsulfonamido)-2-{4-[2-(piperidin-4-yl)ethoxy]benzamido}ethylthiophosphonic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium carbonate / 1,4-dioxane; water / 1 h / 20 °C

2.1: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / tetrahydrofuran / 21 h / 0 - 20 °C / Inert atmosphere

3.1: water; sodium hydroxide / ethanol / 16 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.25 h / 20 °C

4.2: 16 h / 20 °C

5.1: chlorotriisopropylsilane; water; trifluoroacetic acid / 16 h / 20 °C

6.1: N,O-bis-(trimethylsilyl)-acetamide; sulfur / dichloromethane / 0 - 20 °C / Inert atmosphere

With N,O-bis-(trimethylsilyl)-acetamide; chlorotriisopropylsilane; tributylphosphine; water; sodium carbonate; sulfur; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; sodium hydroxide; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; 2.1: Mitsunobu reaction;
DOI:10.1021/jm2013826

Reference yield:

: 1354924-73-4
2-{N-[(9H-fluoren-9-yl)methoxy]carbonylamino}-1-(phenylsulfonamido)ethylphosphinic acid

: 1354924-66-5
1-(phenylsulfonamido)-2-{4-[2-(piperidin-4-yl)ethoxy]benzamido}ethylthiophosphonic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: piperidine / N,N-dimethyl-formamide / 2 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.25 h / 20 °C

2.2: 16 h / 20 °C

3.1: chlorotriisopropylsilane; water; trifluoroacetic acid / 16 h / 20 °C

4.1: N,O-bis-(trimethylsilyl)-acetamide; sulfur / dichloromethane / 0 - 20 °C / Inert atmosphere

With piperidine; N,O-bis-(trimethylsilyl)-acetamide; chlorotriisopropylsilane; water; sulfur; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm2013826