2-{N-[(9H-fluoren-9-yl)methoxy]carbonylamino}-1-(phenylsulfonamido)ethylphosphinic acid

Base Information

Chemical Name:2-{N-[(9H-fluoren-9-yl)methoxy]carbonylamino}-1-(phenylsulfonamido)ethylphosphinic acid
CAS No.:1354924-73-4
Molecular Formula:C₂₃H₂₃N₂O₆PS
Molecular Weight:486.485
Hs Code.:

Synonyms:2-{N-[(9H-fluoren-9-yl)methoxy]carbonylamino}-1-(phenylsulfonamido)ethylphosphinic acid

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Chemical Property of 2-{N-[(9H-fluoren-9-yl)methoxy]carbonylamino}-1-(phenylsulfonamido)ethylphosphinic acid

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Technology Process of 2-{N-[(9H-fluoren-9-yl)methoxy]carbonylamino}-1-(phenylsulfonamido)ethylphosphinic acid

There total 5 articles about 2-{N-[(9H-fluoren-9-yl)methoxy]carbonylamino}-1-(phenylsulfonamido)ethylphosphinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1354924-72-3
2-{N-[(9H-fluoren-9-yl)methoxy]carbonylamino}-1-aminoethylphosphinic acid

: 98-09-9
benzenesulfonyl chloride

: 1354924-73-4
2-{N-[(9H-fluoren-9-yl)methoxy]carbonylamino}-1-(phenylsulfonamido)ethylphosphinic acid

Guidance literature:: With sodium carbonate; In 1,4-dioxane; water; at 20 ℃; for 3h;
DOI:10.1021/jm2013826

Reference yield:

: 1354924-70-1
(9H-fluoren-9-yl)methyl [2-(hydroxyimino)ethyl]carbamate

: 1354924-73-4
2-{N-[(9H-fluoren-9-yl)methoxy]carbonylamino}-1-(phenylsulfonamido)ethylphosphinic acid

Guidance literature:: Multi-step reaction with 2 steps

1: hypophosphorous acid / methanol / 4 h / Reflux

2: sodium carbonate / 1,4-dioxane; water / 3 h / 20 °C

With hypophosphorous acid; sodium carbonate; In 1,4-dioxane; methanol; water;
DOI:10.1021/jm2013826

Reference yield:

: 28920-43-6
(fluorenylmethoxy)carbonyl chloride

: 1354924-73-4
2-{N-[(9H-fluoren-9-yl)methoxy]carbonylamino}-1-(phenylsulfonamido)ethylphosphinic acid

Guidance literature:: Multi-step reaction with 5 steps

1: sodium carbonate / water / 2 h / 20 °C

2: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 16 h / 20 °C

3: hydroxylamine hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 20 °C

4: hypophosphorous acid / methanol / 4 h / Reflux

5: sodium carbonate / 1,4-dioxane; water / 3 h / 20 °C

With hydroxylamine hydrochloride; hypophosphorous acid; sodium carbonate; N-ethyl-N,N-diisopropylamine; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In 1,4-dioxane; methanol; dichloromethane; water; dimethyl sulfoxide;
DOI:10.1021/jm2013826