7-(4-(trifluoromethyl)phenyl)-1,2-dihydro-6-methoxy-2,2,4-trimethylquinoline

Base Information

Chemical Name:7-(4-(trifluoromethyl)phenyl)-1,2-dihydro-6-methoxy-2,2,4-trimethylquinoline
CAS No.:1265153-58-9
Molecular Formula:C₂₀H₂₀F₃NO
Molecular Weight:347.38
Hs Code.:

Synonyms:7-(4-(trifluoromethyl)phenyl)-1,2-dihydro-6-methoxy-2,2,4-trimethylquinoline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 7-(4-(trifluoromethyl)phenyl)-1,2-dihydro-6-methoxy-2,2,4-trimethylquinoline

Chemical Property:

Purity/Quality:

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Technology Process of 7-(4-(trifluoromethyl)phenyl)-1,2-dihydro-6-methoxy-2,2,4-trimethylquinoline

There total 3 articles about 7-(4-(trifluoromethyl)phenyl)-1,2-dihydro-6-methoxy-2,2,4-trimethylquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1265153-57-8
7-bromo-1,2-dihydro-6-methoxy-2,2,4-trimethylquinoline

: 128796-39-4
4-trifluoromethylphenylboronic acid

: 1265153-58-9
7-(4-(trifluoromethyl)phenyl)-1,2-dihydro-6-methoxy-2,2,4-trimethylquinoline

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In ethanol; toluene; for 3h; Reflux;
DOI:10.1016/j.bmc.2010.11.003

Reference yield:

: 19056-41-8
3-bromo-p-anisidine

: 1265153-58-9
7-(4-(trifluoromethyl)phenyl)-1,2-dihydro-6-methoxy-2,2,4-trimethylquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: iodine / toluene / 36 h / Reflux

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / ethanol; toluene / 3 h / Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; iodine; potassium carbonate; In ethanol; toluene; 1: Skraup reaction / 2: Suzuki coupling;
DOI:10.1016/j.bmc.2010.11.003

Reference yield:

: 5197-28-4
2-bromo-4-nitroanisole

: 1265153-58-9
7-(4-(trifluoromethyl)phenyl)-1,2-dihydro-6-methoxy-2,2,4-trimethylquinoline

Guidance literature:: Multi-step reaction with 3 steps

1: tin(ll) chloride

2: iodine / toluene / 36 h / Reflux

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / ethanol; toluene / 3 h / Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; iodine; potassium carbonate; tin(ll) chloride; In ethanol; toluene; 2: Skraup reaction / 3: Suzuki coupling;
DOI:10.1016/j.bmc.2010.11.003