1-benzyl-7-(4-(trifluoromethyl)phenyl)-1,2-dihydro-2,2,4-trimethylquinolin-6-yl acetate

Base Information

Chemical Name:1-benzyl-7-(4-(trifluoromethyl)phenyl)-1,2-dihydro-2,2,4-trimethylquinolin-6-yl acetate
CAS No.:1265153-72-7
Molecular Formula:C₂₈H₂₆F₃NO₂
Molecular Weight:465.515
Hs Code.:

Synonyms:1-benzyl-7-(4-(trifluoromethyl)phenyl)-1,2-dihydro-2,2,4-trimethylquinolin-6-yl acetate

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Chemical Property of 1-benzyl-7-(4-(trifluoromethyl)phenyl)-1,2-dihydro-2,2,4-trimethylquinolin-6-yl acetate

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Technology Process of 1-benzyl-7-(4-(trifluoromethyl)phenyl)-1,2-dihydro-2,2,4-trimethylquinolin-6-yl acetate

There total 6 articles about 1-benzyl-7-(4-(trifluoromethyl)phenyl)-1,2-dihydro-2,2,4-trimethylquinolin-6-yl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1265153-84-1
1-benzyl-7-(4-(trifluoromethyl)phenyl)-1,2-dihydro-2,2,4-trimethylquinolin-6-ol

: 75-36-5
acetyl chloride

: 1265153-72-7
1-benzyl-7-(4-(trifluoromethyl)phenyl)-1,2-dihydro-2,2,4-trimethylquinolin-6-yl acetate

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; Inert atmosphere;
DOI:10.1016/j.bmc.2010.11.003

Reference yield:

: 1265153-58-9
7-(4-(trifluoromethyl)phenyl)-1,2-dihydro-6-methoxy-2,2,4-trimethylquinoline

: 1265153-72-7
1-benzyl-7-(4-(trifluoromethyl)phenyl)-1,2-dihydro-2,2,4-trimethylquinolin-6-yl acetate

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen bromide / 7 h / Reflux; Inert atmosphere

2: triethylamine / toluene / Reflux; Inert atmosphere

3: triethylamine / dichloromethane / 20 °C / Inert atmosphere

With hydrogen bromide; triethylamine; In dichloromethane; toluene;
DOI:10.1016/j.bmc.2010.11.003

Reference yield:

: 5197-28-4
2-bromo-4-nitroanisole

: 1265153-72-7
1-benzyl-7-(4-(trifluoromethyl)phenyl)-1,2-dihydro-2,2,4-trimethylquinolin-6-yl acetate

Guidance literature:: Multi-step reaction with 6 steps

1: tin(ll) chloride

2: iodine / toluene / 36 h / Reflux

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / ethanol; toluene / 3 h / Reflux

4: hydrogen bromide / 7 h / Reflux; Inert atmosphere

5: triethylamine / toluene / Reflux; Inert atmosphere

6: triethylamine / dichloromethane / 20 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen bromide; iodine; potassium carbonate; triethylamine; tin(ll) chloride; In ethanol; dichloromethane; toluene; 2: Skraup reaction / 3: Suzuki coupling;
DOI:10.1016/j.bmc.2010.11.003