tert-butyl ((1R,2R)-2-(2-amino-4-(trifluoromethyl)phenoxy)-2,3-dihydro-1H-inden-1-yl)carbamate

Base Information

• Chemical Name: tert-butyl ((1R,2R)-2-(2-amino-4-(trifluoromethyl)phenoxy)-2,3-dihydro-1H-inden-1-yl)carbamate
• CAS No.: 1402743-81-0
• Molecular Formula: C₂₁H₂₃F₃N₂O₃
• Molecular Weight: 408.42

Synonyms:tert-butyl ((1R,2R)-2-(2-amino-4-(trifluoromethyl)phenoxy)-2,3-dihydro-1H-inden-1-yl)carbamate

Chemical Property of tert-butyl ((1R,2R)-2-(2-amino-4-(trifluoromethyl)phenoxy)-2,3-dihydro-1H-inden-1-yl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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Technology Process of tert-butyl ((1R,2R)-2-(2-amino-4-(trifluoromethyl)phenoxy)-2,3-dihydro-1H-inden-1-yl)carbamate

There total 4 articles about tert-butyl ((1R,2R)-2-(2-amino-4-(trifluoromethyl)phenoxy)-2,3-dihydro-1H-inden-1-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

tert-butyl ((1R,2R)-2-(2-nitro-4-(trifluoromethyl)phenoxy)-2,3-dihydro-1H-inden-1-yl)carbamate (1402743-80-9) → tert-butyl ((1R,2R)-2-(2-amino-4-(trifluoromethyl)phenoxy)-2,3-dihydro-1H-inden-1-yl)carbamate (1402743-81-0)

Guidance literature:

With 5%-palladium/activated carbon; hydrogen; In ethyl acetate;

DOI:10.1002/anie.201203852

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → tert-butyl ((1R,2R)-2-(2-amino-4-(trifluoromethyl)phenoxy)-2,3-dihydro-1H-inden-1-yl)carbamate (1402743-81-0)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium carbonate / tetrahydrofuran; water / 0 - 20 °C

2: lithium hexamethyldisilazane / tetrahydrofuran / -40 - 20 °C

3: 5%-palladium/activated carbon; hydrogen / ethyl acetate

With 5%-palladium/activated carbon; hydrogen; sodium carbonate; lithium hexamethyldisilazane; In tetrahydrofuran; water; ethyl acetate;

DOI:10.1002/anie.201203852

Reference yield:

(1R,2R)-1-aminoindan-2-ol (163061-73-2) → tert-butyl ((1R,2R)-2-(2-amino-4-(trifluoromethyl)phenoxy)-2,3-dihydro-1H-inden-1-yl)carbamate (1402743-81-0)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium carbonate / tetrahydrofuran; water / 0 - 20 °C

2: lithium hexamethyldisilazane / tetrahydrofuran / -40 - 20 °C

3: 5%-palladium/activated carbon; hydrogen / ethyl acetate

With 5%-palladium/activated carbon; hydrogen; sodium carbonate; lithium hexamethyldisilazane; In tetrahydrofuran; water; ethyl acetate;

DOI:10.1002/anie.201203852

upstream raw materials:

tert-butyl ((1R,2R)-2-(2-nitro-4-(trifluoromethyl)phenoxy)-2,3-dihydro-1H-inden-1-yl)carbamate

di-tert-butyl dicarbonate

(1R,2R)-1-aminoindan-2-ol

tert-butyl [(1R,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-carbamate

Downstream raw materials:

C₂₈H₂₃F₉N₄O₃

1-(2-(((1R,2R)-1-amino-2,3-dihydro-1H-inden-2-yl)oxy)-5-(trifluoromethyl)phenyl)-3-(3,5-bis(trifluoromethyl)phenyl)urea

C₁₉H₂₀F₃N₃O₂

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