N₂-cyclopentyl-5'-O-(4,4'-dimethoxytriphenylmethyl)-2'-O-(tert-butyldimethylsilyl)-O₆-(2-(p-nitrophenyl)ethyl)guanosine

Base Information

• Chemical Name: N₂-cyclopentyl-5'-O-(4,4'-dimethoxytriphenylmethyl)-2'-O-(tert-butyldimethylsilyl)-O₆-(2-(p-nitrophenyl)ethyl)guanosine
• CAS No.: 1311147-64-4
• Molecular Formula: C₅₀H₆₀N₆O₉Si
• Molecular Weight: 917.147

Synonyms:N₂-cyclopentyl-5'-O-(4,4'-dimethoxytriphenylmethyl)-2'-O-(tert-butyldimethylsilyl)-O₆-(2-(p-nitrophenyl)ethyl)guanosine

Chemical Property of N₂-cyclopentyl-5'-O-(4,4'-dimethoxytriphenylmethyl)-2'-O-(tert-butyldimethylsilyl)-O₆-(2-(p-nitrophenyl)ethyl)guanosine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N₂-cyclopentyl-5'-O-(4,4'-dimethoxytriphenylmethyl)-2'-O-(tert-butyldimethylsilyl)-O₆-(2-(p-nitrophenyl)ethyl)guanosine

There total 7 articles about N₂-cyclopentyl-5'-O-(4,4'-dimethoxytriphenylmethyl)-2'-O-(tert-butyldimethylsilyl)-O₆-(2-(p-nitrophenyl)ethyl)guanosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

N2-cyclopentyl-5'-O-(4,4'-dimethoxytriphenylmethyl)-O6-(2-(p-nitrophenyl)ethyl)guanosine (1311147-63-3) + tert-butyldimethylsilyl chloride (18162-48-6) → N2-cyclopentyl-5'-O-(4,4'-dimethoxytriphenylmethyl)-2'-O-(tert-butyldimethylsilyl)-O6-(2-(p-nitrophenyl)ethyl)guanosine (1311147-64-4)

Guidance literature:

With silver nitrate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 12h; Inert atmosphere;

DOI:10.1021/ja202492e

Reference yield:

(2R,3R,4S,5R)-2-(2-amino-6-(4-nitrophenethoxy)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol (91592-85-7) → N2-cyclopentyl-5'-O-(4,4'-dimethoxytriphenylmethyl)-2'-O-(tert-butyldimethylsilyl)-O6-(2-(p-nitrophenyl)ethyl)guanosine (1311147-64-4)

Guidance literature:

Multi-step reaction with 4 steps

1: pyridine; hydrogen fluoride / tetrahydrofuran; 2-Methyl-2-nitropropane / Inert atmosphere

2: methanol / 12 h / 20 °C / Inert atmosphere

3: pyridine; dmap / 30 h / 20 °C / Inert atmosphere

4: silver nitrate; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 12 h / 20 °C / Inert atmosphere

With pyridine; dmap; hydrogen fluoride; silver nitrate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; 2-Methyl-2-nitropropane;

DOI:10.1021/ja202492e

Reference yield:

N2-cyclopentyl-O6-(2-(p-nitrophenyl)ethyl)guanosine (1311147-62-2) → N2-cyclopentyl-5'-O-(4,4'-dimethoxytriphenylmethyl)-2'-O-(tert-butyldimethylsilyl)-O6-(2-(p-nitrophenyl)ethyl)guanosine (1311147-64-4)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine; dmap / 30 h / 20 °C / Inert atmosphere

2: silver nitrate; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 12 h / 20 °C / Inert atmosphere

With pyridine; dmap; silver nitrate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran;

DOI:10.1021/ja202492e

upstream raw materials:

Acetic acid (2R,3R,4R,5R)-4-acetoxy-5-acetoxymethyl-2-(2-acetylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester

N₂-cyclopentyl-O₆-(2-(p-nitrophenyl)ethyl)guanosine

N₂-cyclopentyl-5'-O-(4,4'-dimethoxytriphenylmethyl)-O₆-(2-(p-nitrophenyl)ethyl)guanosine

tert-butyldimethylsilyl chloride

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1311147-64-4 N₂-cyclopentyl-5'-O-(4,4'-dimethoxytriphenylmethyl)-2'-O-(tert-butyldimethylsilyl)-O₆-(2-(p-nitrophenyl)ethyl)guanosine

Send

Send

Metric Ton KG G Pound L ML

Send

Send