9-(3,4-dimethoxy-phenyl)-3,3-dimethyl-1,5-dioxa-spiro[5.5]undecane-9-carbaldehyde

Base Information

Chemical Name:9-(3,4-dimethoxy-phenyl)-3,3-dimethyl-1,5-dioxa-spiro[5.5]undecane-9-carbaldehyde
CAS No.:735270-01-6
Molecular Formula:C₂₀H₂₈O₅
Molecular Weight:348.439
Hs Code.:

Synonyms:9-(3,4-dimethoxy-phenyl)-3,3-dimethyl-1,5-dioxa-spiro[5.5]undecane-9-carbaldehyde

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Chemical Property of 9-(3,4-dimethoxy-phenyl)-3,3-dimethyl-1,5-dioxa-spiro[5.5]undecane-9-carbaldehyde

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Technology Process of 9-(3,4-dimethoxy-phenyl)-3,3-dimethyl-1,5-dioxa-spiro[5.5]undecane-9-carbaldehyde

There total 5 articles about 9-(3,4-dimethoxy-phenyl)-3,3-dimethyl-1,5-dioxa-spiro[5.5]undecane-9-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 735269-99-5
9-(3,4-dimethoxy-phenyl)-3,3-dimethyl-1,5-dioxa-spiro[5.5]undecane-9-carbonitrile

: 735270-01-6
9-(3,4-dimethoxy-phenyl)-3,3-dimethyl-1,5-dioxa-spiro[5.5]undecane-9-carbaldehyde

Guidance literature:: With diisobutylaluminium hydride; In dichloromethane; at 0 ℃; for 0.5h;
DOI:10.1016/j.tetlet.2004.05.021

Reference yield:

: 93-17-4
3,4-dimethoxyphenylacetonitrile

: 735270-01-6
9-(3,4-dimethoxy-phenyl)-3,3-dimethyl-1,5-dioxa-spiro[5.5]undecane-9-carbaldehyde

Guidance literature:: Multi-step reaction with 5 steps

1: 76 percent / NaOH; TBAHSO₄ / H₂O / 0.5 h / 0 °C

2: 89 percent / NaH / 1,2-dimethoxy-ethane / 3 h / Heating

3: 87 percent / NaCl; H₂O / dimethylsulfoxide / 6 h / 140 °C

4: 95 percent / PPTS / benzene / 3 h / Heating

5: 100 percent / DIBAL-H / CH₂Cl₂ / 0.5 h / 0 °C

With sodium hydroxide; water; tetra(n-butyl)ammonium hydrogensulfate; pyridinium p-toluenesulfonate; sodium hydride; diisobutylaluminium hydride; sodium chloride; In 1,2-dimethoxyethane; dichloromethane; water; dimethyl sulfoxide; benzene; 1: Michael addition / 2: Dieckmann condensation / 3: Krapcho's demethoxycarbonylation;
DOI:10.1016/j.tetlet.2004.05.021

Reference yield:

: 61330-09-4
dimethyl 4-cyano-4-(3,4-dimethoxyphenyl)heptanedioate

: 735270-01-6
9-(3,4-dimethoxy-phenyl)-3,3-dimethyl-1,5-dioxa-spiro[5.5]undecane-9-carbaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1: 89 percent / NaH / 1,2-dimethoxy-ethane / 3 h / Heating

2: 87 percent / NaCl; H₂O / dimethylsulfoxide / 6 h / 140 °C

3: 95 percent / PPTS / benzene / 3 h / Heating

4: 100 percent / DIBAL-H / CH₂Cl₂ / 0.5 h / 0 °C

With water; pyridinium p-toluenesulfonate; sodium hydride; diisobutylaluminium hydride; sodium chloride; In 1,2-dimethoxyethane; dichloromethane; dimethyl sulfoxide; benzene; 1: Dieckmann condensation / 2: Krapcho's demethoxycarbonylation;
DOI:10.1016/j.tetlet.2004.05.021