1-(3,4-dihydroisoquinolin-2(1H)-yl)-3-((3'-(hydroxymethyl)-[1,1'-biphenyl]-3-yl)oxy)propan-2-ol formate

Base Information

Chemical Name:1-(3,4-dihydroisoquinolin-2(1H)-yl)-3-((3'-(hydroxymethyl)-[1,1'-biphenyl]-3-yl)oxy)propan-2-ol formate
CAS No.:1616098-86-2
Molecular Formula:CH₂O₂*C₂₅H₂₇NO₃
Molecular Weight:435.52
Hs Code.:

Synonyms:1-(3,4-dihydroisoquinolin-2(1H)-yl)-3-((3'-(hydroxymethyl)-[1,1'-biphenyl]-3-yl)oxy)propan-2-ol formate

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Chemical Property of 1-(3,4-dihydroisoquinolin-2(1H)-yl)-3-((3'-(hydroxymethyl)-[1,1'-biphenyl]-3-yl)oxy)propan-2-ol formate

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Technology Process of 1-(3,4-dihydroisoquinolin-2(1H)-yl)-3-((3'-(hydroxymethyl)-[1,1'-biphenyl]-3-yl)oxy)propan-2-ol formate

There total 4 articles about 1-(3,4-dihydroisoquinolin-2(1H)-yl)-3-((3'-(hydroxymethyl)-[1,1'-biphenyl]-3-yl)oxy)propan-2-ol formate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 64-18-6
formic acid

: 15852-73-0
(3-Bromophenyl)methanol

: 1616099-47-8
1-(3,4-dihydroisoquinolin-2(1H)-yl)-3-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)propan-2-ol

: 1616098-86-2
1-(3,4-dihydroisoquinolin-2(1H)-yl)-3-((3'-(hydroxymethyl)-[1,1'-biphenyl]-3-yl)oxy)propan-2-ol formate

Guidance literature:: (3-Bromophenyl)methanol; 1-(3,4-dihydroisoquinolin-2(1H)-yl)-3-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)propan-2-ol; With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate; In 1,4-dioxane; water; at 100 ℃; for 12h; Inert atmosphere;

formic acid;

Reference yield:

: 591-20-8
3-Bromophenol

: 1616098-86-2
1-(3,4-dihydroisoquinolin-2(1H)-yl)-3-((3'-(hydroxymethyl)-[1,1'-biphenyl]-3-yl)oxy)propan-2-ol formate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydride / N,N-dimethyl-formamide / 16 h / 9 °C

2: methanol / 16 h / 8 °C / Reflux

3: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / dimethyl sulfoxide / 4 h / 20 - 100 °C

4: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate / 1,4-dioxane; water / 12 h / 100 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate; potassium acetate; sodium hydride; In 1,4-dioxane; methanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 1088176-04-8
1-(3-bromophenoxy)-3-(3,4-dihydroisoquinolin-2(1H)-yl)propan-2-ol

: 1616098-86-2
1-(3,4-dihydroisoquinolin-2(1H)-yl)-3-((3'-(hydroxymethyl)-[1,1'-biphenyl]-3-yl)oxy)propan-2-ol formate

Guidance literature:: Multi-step reaction with 2 steps

1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / dimethyl sulfoxide / 4 h / 20 - 100 °C

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate / 1,4-dioxane; water / 12 h / 100 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate; potassium acetate; In 1,4-dioxane; water; dimethyl sulfoxide;