Propionic acid (1R,2S)-3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-1-[(S)-1-methyl-2-(toluene-4-sulfonyloxy)-ethyl]-propyl ester

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Chemical Name:Propionic acid (1R,2S)-3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-1-[(S)-1-methyl-2-(toluene-4-sulfonyloxy)-ethyl]-propyl ester
CAS No.:183293-44-9
Molecular Formula:C₂₃H₄₀O₆SSi
Molecular Weight:472.719
Hs Code.:

Synonyms:Propionic acid (1R,2S)-3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-1-[(S)-1-methyl-2-(toluene-4-sulfonyloxy)-ethyl]-propyl ester

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Chemical Property of Propionic acid (1R,2S)-3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-1-[(S)-1-methyl-2-(toluene-4-sulfonyloxy)-ethyl]-propyl ester

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Technology Process of Propionic acid (1R,2S)-3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-1-[(S)-1-methyl-2-(toluene-4-sulfonyloxy)-ethyl]-propyl ester

There total 11 articles about Propionic acid (1R,2S)-3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-1-[(S)-1-methyl-2-(toluene-4-sulfonyloxy)-ethyl]-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 123-62-6
propionic acid anhydride

: 183293-43-8
Toluene-4-sulfonic acid (2S,3R,4S)-5-(tert-butyl-dimethyl-silanyloxy)-3-hydroxy-2,4-dimethyl-pentyl ester

: 183293-44-9
Propionic acid (1R,2S)-3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-1-[(S)-1-methyl-2-(toluene-4-sulfonyloxy)-ethyl]-propyl ester

Guidance literature:: With dmap; triethylamine; In dichloromethane; for 0.5h; Ambient temperature;
DOI:10.1021/jo9809433

Reference yield:

: 108393-28-8
(2S,3R,4S)-5-benzyloxy-2,3-dimethylpentane-1,4-diol

: 183293-44-9
Propionic acid (1R,2S)-3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-1-[(S)-1-methyl-2-(toluene-4-sulfonyloxy)-ethyl]-propyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: Et₃N, DMAP / CH₂Cl₂ / 1 h / Ambient temperature

2: 78 percent / H₂ / Pd/C / ethanol / 7.5 h / 2280 Torr

3: Et₃N, DMAP / CH₂Cl₂ / 3 h / 0 °C

4: 95 percent / Et₃N, DMAP / CH₂Cl₂ / 0.5 h / Ambient temperature

With dmap; hydrogen; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane;
DOI:10.1021/jo9809433

Reference yield:

: 183293-40-5
(2S,3S,4S)-1-Benzyloxy-5-(tert-butyl-dimethyl-silanyloxy)-2,4-dimethyl-pentan-3-ol

: 183293-44-9
Propionic acid (1R,2S)-3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-1-[(S)-1-methyl-2-(toluene-4-sulfonyloxy)-ethyl]-propyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 78 percent / H₂ / Pd/C / ethanol / 7.5 h / 2280 Torr

2: Et₃N, DMAP / CH₂Cl₂ / 3 h / 0 °C

3: 95 percent / Et₃N, DMAP / CH₂Cl₂ / 0.5 h / Ambient temperature

With dmap; hydrogen; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane;
DOI:10.1021/jo9809433