Technology Process of (2S,3R)-2-[4-(benzyloxy)butyl]-3-(chloromethyl)oxirane
There total 6 articles about (2S,3R)-2-[4-(benzyloxy)butyl]-3-(chloromethyl)oxirane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: oxalyl dichloride; triethylamine / dichloromethane; dimethyl sulfoxide / 1 h / -78 - 20 °C / Inert atmosphere
2.1: benzene / 1 h / 80 °C
3.1: lithium aluminium tetrahydride; aluminum (III) chloride / diethyl ether / 0.5 h / 0 °C / Inert atmosphere
4.1: titanium(IV) isopropylate; diethyl (2R,3R)-tartrate / dichloromethane / 0.5 h / -20 °C / Molecular sieve
4.2: 8 h / -20 °C / Molecular sieve
5.1: sodium hydrogencarbonate; triphenylphosphine / tetrachloromethane / 3 h / Reflux
With
titanium(IV) isopropylate; aluminum (III) chloride; lithium aluminium tetrahydride; oxalyl dichloride; diethyl (2R,3R)-tartrate; sodium hydrogencarbonate; triethylamine; triphenylphosphine;
In
tetrachloromethane; diethyl ether; dichloromethane; dimethyl sulfoxide; benzene;
1.1: Swern oxidation / 2.1: Wittig reaction / 4.1: Sharpless epoxidation;
DOI:10.1055/s-0031-1290156
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: benzene / 1 h / 80 °C
2.1: lithium aluminium tetrahydride; aluminum (III) chloride / diethyl ether / 0.5 h / 0 °C / Inert atmosphere
3.1: titanium(IV) isopropylate; diethyl (2R,3R)-tartrate / dichloromethane / 0.5 h / -20 °C / Molecular sieve
3.2: 8 h / -20 °C / Molecular sieve
4.1: sodium hydrogencarbonate; triphenylphosphine / tetrachloromethane / 3 h / Reflux
With
titanium(IV) isopropylate; aluminum (III) chloride; lithium aluminium tetrahydride; diethyl (2R,3R)-tartrate; sodium hydrogencarbonate; triphenylphosphine;
In
tetrachloromethane; diethyl ether; dichloromethane; benzene;
1.1: Wittig reaction / 3.1: Sharpless epoxidation;
DOI:10.1055/s-0031-1290156
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: titanium(IV) isopropylate; diethyl (2R,3R)-tartrate / dichloromethane / 0.5 h / -20 °C / Molecular sieve
1.2: 8 h / -20 °C / Molecular sieve
2.1: sodium hydrogencarbonate; triphenylphosphine / tetrachloromethane / 3 h / Reflux
With
titanium(IV) isopropylate; diethyl (2R,3R)-tartrate; sodium hydrogencarbonate; triphenylphosphine;
In
tetrachloromethane; dichloromethane;
1.1: Sharpless epoxidation;
DOI:10.1055/s-0031-1290156
