(S)-7-(benzyloxy)hept-1-yn-3-ol

Base Information

Chemical Name:(S)-7-(benzyloxy)hept-1-yn-3-ol
CAS No.:1374783-95-5
Molecular Formula:C₁₄H₁₈O₂
Molecular Weight:218.296
Hs Code.:

Synonyms:(S)-7-(benzyloxy)hept-1-yn-3-ol

Suppliers and Price of (S)-7-(benzyloxy)hept-1-yn-3-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-7-(benzyloxy)hept-1-yn-3-ol

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Technology Process of (S)-7-(benzyloxy)hept-1-yn-3-ol

There total 8 articles about (S)-7-(benzyloxy)hept-1-yn-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1374783-94-4
(2S,3R)-2-[4-(benzyloxy)butyl]-3-(chloromethyl)oxirane

: 1374783-95-5
(S)-7-(benzyloxy)hept-1-yn-3-ol

Guidance literature:: With iron nitrate; ammonia; lithium; In tetrahydrofuran; at -33 ℃; for 2h;
DOI:10.1055/s-0031-1290156

Reference yield:

: 1158076-88-0
((2S,3S)-3-(4-(benzyloxy)butyl)oxiran-2-yl)methanol

: 1374783-95-5
(S)-7-(benzyloxy)hept-1-yn-3-ol

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydrogencarbonate; triphenylphosphine / tetrachloromethane / 3 h / Reflux

2: iron nitrate; ammonia; lithium / tetrahydrofuran / 2 h / -33 °C

With iron nitrate; ammonia; lithium; sodium hydrogencarbonate; triphenylphosphine; In tetrahydrofuran; tetrachloromethane; 2: Birch reduction;
DOI:10.1055/s-0031-1290156

Reference yield:

: 111-29-5
1 ,5-pentanediol

: 1374783-95-5
(S)-7-(benzyloxy)hept-1-yn-3-ol

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 0 - 20 °C

1.2: 10.17 h / 0 - 20 °C

2.1: oxalyl dichloride; triethylamine / dichloromethane; dimethyl sulfoxide / 1 h / -78 - 20 °C / Inert atmosphere

3.1: benzene / 1 h / 80 °C

4.1: lithium aluminium tetrahydride; aluminum (III) chloride / diethyl ether / 0.5 h / 0 °C / Inert atmosphere

5.1: titanium(IV) isopropylate; diethyl (2R,3R)-tartrate / dichloromethane / 0.5 h / -20 °C / Molecular sieve

5.2: 8 h / -20 °C / Molecular sieve

6.1: sodium hydrogencarbonate; triphenylphosphine / tetrachloromethane / 3 h / Reflux

7.1: iron nitrate; ammonia; lithium / tetrahydrofuran / 2 h / -33 °C

With titanium(IV) isopropylate; aluminum (III) chloride; lithium aluminium tetrahydride; oxalyl dichloride; iron nitrate; diethyl (2R,3R)-tartrate; ammonia; lithium; sodium hydride; sodium hydrogencarbonate; triethylamine; triphenylphosphine; In tetrahydrofuran; tetrachloromethane; diethyl ether; dichloromethane; dimethyl sulfoxide; mineral oil; benzene; 2.1: Swern oxidation / 3.1: Wittig reaction / 5.1: Sharpless epoxidation / 7.1: Birch reduction;
DOI:10.1055/s-0031-1290156