acrylic acid (E)-(R)-1-allyl-4-{(4S,6S)-2,2-dimethyl-6-phenethyl-[1,3]dioxan-4-yl}-but-2-enyl ester

Base Information

Chemical Name:acrylic acid (E)-(R)-1-allyl-4-{(4S,6S)-2,2-dimethyl-6-phenethyl-[1,3]dioxan-4-yl}-but-2-enyl ester
CAS No.:548483-78-9
Molecular Formula:C₂₄H₃₂O₄
Molecular Weight:384.516
Hs Code.:

Synonyms:acrylic acid (E)-(R)-1-allyl-4-{(4S,6S)-2,2-dimethyl-6-phenethyl-[1,3]dioxan-4-yl}-but-2-enyl ester

Suppliers and Price of acrylic acid (E)-(R)-1-allyl-4-{(4S,6S)-2,2-dimethyl-6-phenethyl-[1,3]dioxan-4-yl}-but-2-enyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of acrylic acid (E)-(R)-1-allyl-4-{(4S,6S)-2,2-dimethyl-6-phenethyl-[1,3]dioxan-4-yl}-but-2-enyl ester

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Technology Process of acrylic acid (E)-(R)-1-allyl-4-{(4S,6S)-2,2-dimethyl-6-phenethyl-[1,3]dioxan-4-yl}-but-2-enyl ester

There total 20 articles about acrylic acid (E)-(R)-1-allyl-4-{(4S,6S)-2,2-dimethyl-6-phenethyl-[1,3]dioxan-4-yl}-but-2-enyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 814-68-6,25189-84-8
acryloyl chloride

: 548483-77-8
(E)-(R)-7-((4S,6S)-2,2-Dimethyl-6-phenethyl-[1,3]dioxan-4-yl)-hepta-1,5-dien-4-ol

: 548483-78-9
acrylic acid (E)-(R)-1-allyl-4-{(4S,6S)-2,2-dimethyl-6-phenethyl-[1,3]dioxan-4-yl}-but-2-enyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at -78 ℃;
DOI:10.1021/ol034619s

Reference yield:

: 548483-74-5
(3S,5S)-1-phenyl-7-octene-3,5-diol

: 548483-78-9
acrylic acid (E)-(R)-1-allyl-4-{(4S,6S)-2,2-dimethyl-6-phenethyl-[1,3]dioxan-4-yl}-but-2-enyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / CSA / acetone / 0.33 h / 25 °C

2: 70 percent / imidazolidine-based ruthenium metathesis catalyst / CH₂Cl₂ / 25 °C

3: 84 percent / diethyl ether / 4 h / -78 °C

4: 92 percent / i-Pr₂NEt / CH₂Cl₂ / -78 °C

With imidazolidine-based ruthenium metathesis catalyst; camphor-10-sulfonic acid; N-ethyl-N,N-diisopropylamine; In diethyl ether; dichloromethane; acetone;
DOI:10.1021/ol034619s

Reference yield:

: 548483-75-6
(4S,6S)-4-Allyl-2,2-dimethyl-6-phenethyl-[1,3]dioxane

: 548483-78-9
acrylic acid (E)-(R)-1-allyl-4-{(4S,6S)-2,2-dimethyl-6-phenethyl-[1,3]dioxan-4-yl}-but-2-enyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 70 percent / imidazolidine-based ruthenium metathesis catalyst / CH₂Cl₂ / 25 °C

2: 84 percent / diethyl ether / 4 h / -78 °C

3: 92 percent / i-Pr₂NEt / CH₂Cl₂ / -78 °C

With imidazolidine-based ruthenium metathesis catalyst; N-ethyl-N,N-diisopropylamine; In diethyl ether; dichloromethane;
DOI:10.1021/ol034619s