(3S,5S)-6-p-toluenesulfonyloxy-5-(2-methoxyethoxymethoxy)-3-vinylhexanenitrile

Base Information

Chemical Name:(3S,5S)-6-p-toluenesulfonyloxy-5-(2-methoxyethoxymethoxy)-3-vinylhexanenitrile
CAS No.:93956-75-3
Molecular Formula:C₁₉H₂₇NO₆S
Molecular Weight:397.492
Hs Code.:

Synonyms:(3S,5S)-6-p-toluenesulfonyloxy-5-(2-methoxyethoxymethoxy)-3-vinylhexanenitrile

Suppliers and Price of (3S,5S)-6-p-toluenesulfonyloxy-5-(2-methoxyethoxymethoxy)-3-vinylhexanenitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (3S,5S)-6-p-toluenesulfonyloxy-5-(2-methoxyethoxymethoxy)-3-vinylhexanenitrile

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (3S,5S)-6-p-toluenesulfonyloxy-5-(2-methoxyethoxymethoxy)-3-vinylhexanenitrile

There total 10 articles about (3S,5S)-6-p-toluenesulfonyloxy-5-(2-methoxyethoxymethoxy)-3-vinylhexanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 93929-58-9
(3S,5S)-6-hydroxy-5-(2-methoxyethoxymethoxy)-3-vinylhexanenitrile

: 98-59-9
p-toluenesulfonyl chloride

: 93956-75-3
(3S,5S)-6-p-toluenesulfonyloxy-5-(2-methoxyethoxymethoxy)-3-vinylhexanenitrile

Guidance literature:: In pyridine; at 0 ℃; for 8h;
DOI:10.1016/S0040-4020(01)91304-3

Reference yield:

: (3S,5S)-6-(1-ethoxyethoxy)-5-hydroxy-3-vinylhexanenitrile

: 93956-75-3
(3S,5S)-6-p-toluenesulfonyloxy-5-(2-methoxyethoxymethoxy)-3-vinylhexanenitrile

Guidance literature:: Multi-step reaction with 3 steps

1: 98 percent / i-Pr₂NEt / CH₂Cl₂ / Ambient temperature

2: 94 percent / 75percent AcOH / 0.5 h / 35 °C

3: 83 percent / pyridine / 8 h / 0 °C

With acetic acid; N-ethyl-N,N-diisopropylamine; In pyridine; dichloromethane;
DOI:10.1016/S0040-4020(01)91304-3

Reference yield:

: 74500-40-6
S-4,5-O-isopropylidene-4,5-dihydroxy-2-ethoxycarbonylpentanoic acid ethyl ester

: 93956-75-3
(3S,5S)-6-p-toluenesulfonyloxy-5-(2-methoxyethoxymethoxy)-3-vinylhexanenitrile

Guidance literature:: Multi-step reaction with 7 steps

2: 89 percent / PPTS / CH₂Cl₂ / 18 h / Ambient temperature

3: diisobutylalane / toluene; hexane / 0.08 h / -75 °C

4: 52 percent / 1,2-dimethoxy-ethane / 0.08 h / -10 °C

5: 98 percent / i-Pr₂NEt / CH₂Cl₂ / Ambient temperature

6: 94 percent / 75percent AcOH / 0.5 h / 35 °C

7: 83 percent / pyridine / 8 h / 0 °C

With pyridinium p-toluenesulfonate; Diisobutylaluminium hydride(1 M solution in tetrahydrofuran, 4.9 mL, 4.9 mmol); acetic acid; N-ethyl-N,N-diisopropylamine; In pyridine; 1,2-dimethoxyethane; hexane; dichloromethane; toluene;
DOI:10.1016/S0040-4020(01)91304-3