Technology Process of (2R,5R)-2,5-diphenylcyclopentane-1,1-dicarboxylic acid diethyl ester
There total 3 articles about (2R,5R)-2,5-diphenylcyclopentane-1,1-dicarboxylic acid diethyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
diethyl malonate;
With
15-crown-5; sodium hydride;
In
tetrahydrofuran;
for 1h;
Heating;
(1S,4S)-1,4-diphenyl-1,4-butanediol bis(methanesulfonic acid ester);
In
tetrahydrofuran;
Heating;
DOI:10.1016/j.jorganchem.2006.10.064
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 83 percent / triethylamine / CH2Cl2 / 2 h / -20 °C
2.1: NaH; 15-crown-5 / tetrahydrofuran / 1 h / Heating
2.2: 57 percent / tetrahydrofuran / Heating
With
15-crown-5; sodium hydride; triethylamine;
In
tetrahydrofuran; dichloromethane;
DOI:10.1016/j.jorganchem.2006.10.064
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: (-)-DIP-chlorideTM / tetrahydrofuran / 22 h / -78 - 2 °C
1.2: 7 h / 40 °C / 0.75 Torr
1.3: 57 percent / diethanolamine / diethyl ether / 18.5 h / 0 - 20 °C
2.1: 83 percent / triethylamine / CH2Cl2 / 2 h / -20 °C
3.1: NaH; 15-crown-5 / tetrahydrofuran / 1 h / Heating
3.2: 57 percent / tetrahydrofuran / Heating
With
15-crown-5; sodium hydride; triethylamine; (-)-diisopinocamphenylborane chloride;
In
tetrahydrofuran; dichloromethane;
DOI:10.1016/j.jorganchem.2006.10.064
