163580-98-1

Upstream product

• 124-63-0 methanesulfonyl chloride 
• 163580-95-8 (1S,4S)-1,4-diphenylbutane-1,4-diol 
• 495-71-6 phenacylacetophenone 

Downstream Products

• 188289-37-4 (+)-2-[(2R,5R)-2,5-diphenylpyrrolidin-1-yl]methylpyridine 
• 929721-34-6 (2R,5R)-2,5-diphenylcyclopentane-1,1-dicarboxylic acid diethyl ester 
• 1189240-22-9 (+)-2-[(2R,5R)-2,5-diphenylpyrrolidin-1-yl]methyl-6-methylpyridine 
• 1189240-19-4 (+)-2-[2-[(2R,5R)-2,5-diphenylpyrrolidin-1-yl]ethyl]pyridine 
• 929721-35-7 (2R,5R)-2,5-diphenylcyclopentane-1,1-dimethanol 
• 929721-36-8 (2R,5R)-2,5-diphenylcyclopentane-1,1-dicarbaldehyde 

Relevant academic research and scientific papers

Asymmetric synthesis of trans-2,5-diphenylpyrrolidine: A C2-symmetric chiral amine

(R,R)-2,5-Diphenylpyrrolidine of high enantiomeric purity (>98% e.e.) may be prepared from 1,4-diphenyl-1,4-butanedione in 4 steps and 64% overall yield. A key step is asymmetric reduction of the dione with Ipc2BCl.

A general, enantioselective synthesis of 2-substituted thiomorpholines and thiomorpholine 1,1-dioxides

In the course of our drug discovery programs, we had need to access chiral, 2-substituted thiomorpholines and their oxidized congeners, thiomorpholine 1,1-dioxides. Here, we disclose a high-yielding, general protocol for the enantioselective synthesis of

Synthesis and characterization of new chiral palladium β-diimine complexes

The synthesis and characterization of a range of chiral β-diimine ligands and their complexes with palladium(II) has been investigated. The introduction of chirality can be easily achieved through a combination of both achiral and chiral building blocks.