Trimethyl-((4aS,8aS)-7-methyl-4a-trityloxymethyl-4a,5,6,8a-tetrahydro-2H-chromen-3-yloxy)-silane

Base Information

Chemical Name:Trimethyl-((4aS,8aS)-7-methyl-4a-trityloxymethyl-4a,5,6,8a-tetrahydro-2H-chromen-3-yloxy)-silane
CAS No.:112388-15-5
Molecular Formula:C₃₃H₃₈O₃Si
Molecular Weight:510.748
Hs Code.:

Synonyms:Trimethyl-((4aS,8aS)-7-methyl-4a-trityloxymethyl-4a,5,6,8a-tetrahydro-2H-chromen-3-yloxy)-silane

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Chemical Property of Trimethyl-((4aS,8aS)-7-methyl-4a-trityloxymethyl-4a,5,6,8a-tetrahydro-2H-chromen-3-yloxy)-silane

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Technology Process of Trimethyl-((4aS,8aS)-7-methyl-4a-trityloxymethyl-4a,5,6,8a-tetrahydro-2H-chromen-3-yloxy)-silane

There total 11 articles about Trimethyl-((4aS,8aS)-7-methyl-4a-trityloxymethyl-4a,5,6,8a-tetrahydro-2H-chromen-3-yloxy)-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 75-77-4
chloro-trimethyl-silane

: 112359-17-8
(4aS,8aS)-7-Methyl-4a-trityloxymethyl-4a,5,6,8a-tetrahydro-4H-chromen-3-one

: 112388-15-5
Trimethyl-((4aS,8aS)-7-methyl-4a-trityloxymethyl-4a,5,6,8a-tetrahydro-2H-chromen-3-yloxy)-silane

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 90 ℃; for 4h;

Reference yield:

: 80371-91-1
(3S,5R)-3-Trityloxymethyl-2-oxa-spiro[4.5]dec-6-ene-1,8-dione

: 112388-15-5
Trimethyl-((4aS,8aS)-7-methyl-4a-trityloxymethyl-4a,5,6,8a-tetrahydro-2H-chromen-3-yloxy)-silane

Guidance literature:: Multi-step reaction with 11 steps

1: 10percent H₂SO₄ / acetone

2: DIBAH / tetrahydrofuran

3: p-TsOH / tetrahydrofuran; CH₂Cl₂

4: LAH / tetrahydrofuran

5: NaH / dimethylformamide

6: 1.) PPTS; 2.) DMAP; 3.) PDC / 1.) MeOH; 2.) pyridine; 3.) CH₂Cl₂

7: 2.) c. HCl / 1.) THF; 2.) MeOH, -20 degC, 12 h, then 50 degC, 2 h

8: Na, NH₃ / tetrahydrofuran

9: DMAP / pyridine

10: PDC / CH₂Cl₂ / 1.) NH₃, THF; 2.) pyridine; 3.) CH₂Cl₂

11: 100 percent / Et₃N / dimethylformamide / 4 h / 90 °C

With hydrogenchloride; dmap; lithium aluminium tetrahydride; dipyridinium dichromate; sulfuric acid; ammonia; sodium; pyridinium p-toluenesulfonate; sodium hydride; diisobutylaluminium hydride; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; pyridine; dichloromethane; N,N-dimethyl-formamide; acetone;

Reference yield:

: 112359-23-6
(3S,4aS,8aS)-4a-Hydroxymethyl-7-methyl-3,4,4a,5,6,8a-hexahydro-2H-chromen-3-ol

: 112388-15-5
Trimethyl-((4aS,8aS)-7-methyl-4a-trityloxymethyl-4a,5,6,8a-tetrahydro-2H-chromen-3-yloxy)-silane

Guidance literature:: Multi-step reaction with 3 steps

1: DMAP / pyridine

2: PDC / CH₂Cl₂ / 1.) NH₃, THF; 2.) pyridine; 3.) CH₂Cl₂

3: 100 percent / Et₃N / dimethylformamide / 4 h / 90 °C

With dmap; dipyridinium dichromate; triethylamine; In pyridine; dichloromethane; N,N-dimethyl-formamide;