C₁₈H₁₇⁽²⁾H₃N₂O₃

Base Information

Chemical Name:C₁₈H₁₇⁽²⁾H₃N₂O₃
CAS No.:1315321-03-9
Molecular Formula:C₁₈H₂₀N₂O₃
Molecular Weight:315.345
Hs Code.:

C<sub>18</sub>H<sub>17</sub><sup>(2)</sup>H<sub>3</sub>N<sub>2</sub>O<sub>3</sub>

Synonyms:C₁₈H₁₇⁽²⁾H₃N₂O₃

Suppliers and Price of C₁₈H₁₇⁽²⁾H₃N₂O₃

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of C₁₈H₁₇⁽²⁾H₃N₂O₃

Chemical Property:

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Technology Process of C₁₈H₁₇⁽²⁾H₃N₂O₃

There total 5 articles about C₁₈H₁₇⁽²⁾H₃N₂O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1315321-09-5
methyl 3-acetyl-1-(but-2-yn-1-yl)-6-methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate

: 1315321-03-9
C₁₈H₁₇⁽²⁾H₃N₂O₃

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / methanol / 20 °C / Inert atmosphere

2: caesium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere

3: tetradeuterioacetic acid; water-d2 / 96 h / 110 °C / Inert atmosphere

With tetradeuterioacetic acid; water-d2; potassium carbonate; caesium carbonate; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/ol2015658

Reference yield:

: 1315320-73-0
methyl 1-(but-2-yn-1-yl)-6-methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate

: 1315321-03-9
C₁₈H₁₇⁽²⁾H₃N₂O₃

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere

2: tetradeuterioacetic acid; water-d2 / 96 h / 110 °C / Inert atmosphere

With tetradeuterioacetic acid; water-d2; caesium carbonate; In N,N-dimethyl-formamide;
DOI:10.1021/ol2015658

Reference yield:

: 188780-24-7
5-methoxycarbonyl-6-methyl-4-phenyl-3,4-dihydropyrimidin-2(1H)-one

: 1315321-03-9
C₁₈H₁₇⁽²⁾H₃N₂O₃

Guidance literature:: Multi-step reaction with 5 steps

1: dmap; triethylamine / dichloromethane / 20 °C / Inert atmosphere

2: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 20 °C / Inert atmosphere

3: potassium carbonate / methanol / 20 °C / Inert atmosphere

4: caesium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere

5: tetradeuterioacetic acid; water-d2 / 96 h / 110 °C / Inert atmosphere

With dmap; tetradeuterioacetic acid; di-isopropyl azodicarboxylate; water-d2; potassium carbonate; caesium carbonate; triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; 2: Mitsunobu reaction;
DOI:10.1021/ol2015658