3-(4-fluorophenylsulfonamino)-5-(4-morpholinoquinazolin-6-yl)benzamide

Base Information

Chemical Name:3-(4-fluorophenylsulfonamino)-5-(4-morpholinoquinazolin-6-yl)benzamide
CAS No.:1404227-60-6
Molecular Formula:C₂₅H₂₂FN₅O₄S
Molecular Weight:507.545
Hs Code.:

Synonyms:3-(4-fluorophenylsulfonamino)-5-(4-morpholinoquinazolin-6-yl)benzamide

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Chemical Property of 3-(4-fluorophenylsulfonamino)-5-(4-morpholinoquinazolin-6-yl)benzamide

Chemical Property:

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Technology Process of 3-(4-fluorophenylsulfonamino)-5-(4-morpholinoquinazolin-6-yl)benzamide

There total 8 articles about 3-(4-fluorophenylsulfonamino)-5-(4-morpholinoquinazolin-6-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6307-83-1
3-bromo-5-nitro-benzoic acid

: 1404227-60-6
3-(4-fluorophenylsulfonamino)-5-(4-morpholinoquinazolin-6-yl)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: thionyl chloride / toluene; N,N-dimethyl-formamide / Reflux

2: ammonia / tetrahydrofuran; water / 0.5 h / 20 °C / Cooling with ice

3: hydrogenchloride; tin(II) chloride dihdyrate / 20 °C

4: pyridine / 0 - 20 °C

5: sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water / 2 h / Reflux; Inert atmosphere

With pyridine; hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; thionyl chloride; tin(II) chloride dihdyrate; ammonia; sodium carbonate; In tetrahydrofuran; water; N,N-dimethyl-formamide; toluene; 5: |Suzuki Coupling;
DOI:10.1016/j.ejmech.2014.01.053

Reference yield:

: 1404227-92-4
3-bromo-5-(4-fluorophenylsulfonylamino)benzamide

: 1404227-87-7
C₁₈H₂₄BN₃O₃

: 1404227-60-6
3-(4-fluorophenylsulfonamino)-5-(4-morpholinoquinazolin-6-yl)benzamide

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; In water; for 2h; Reflux; Inert atmosphere;
DOI:10.1016/j.ejmech.2014.01.053

Reference yield:

: 54321-80-1
3-bromo-5-nitrobenzamide

: 1404227-60-6
3-(4-fluorophenylsulfonamino)-5-(4-morpholinoquinazolin-6-yl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride; tin(II) chloride dihdyrate / 20 °C

2: pyridine / 0 - 20 °C

3: sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water / 2 h / Reflux; Inert atmosphere

With pyridine; hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tin(II) chloride dihdyrate; sodium carbonate; In water; 3: |Suzuki Coupling;
DOI:10.1016/j.ejmech.2014.01.053