5-fluoro-2-(4-(4-((4-(methylsulfonyl)piperazin-1-yl)methyl)phenoxy)piperidin-1-yl)pyrimidine

Base Information

Chemical Name:5-fluoro-2-(4-(4-((4-(methylsulfonyl)piperazin-1-yl)methyl)phenoxy)piperidin-1-yl)pyrimidine
CAS No.:1190979-31-7
Molecular Formula:C₂₁H₂₈FN₅O₃S
Molecular Weight:449.549
Hs Code.:

Synonyms:5-fluoro-2-(4-(4-((4-(methylsulfonyl)piperazin-1-yl)methyl)phenoxy)piperidin-1-yl)pyrimidine

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Chemical Property of 5-fluoro-2-(4-(4-((4-(methylsulfonyl)piperazin-1-yl)methyl)phenoxy)piperidin-1-yl)pyrimidine

Chemical Property:

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Technology Process of 5-fluoro-2-(4-(4-((4-(methylsulfonyl)piperazin-1-yl)methyl)phenoxy)piperidin-1-yl)pyrimidine

There total 6 articles about 5-fluoro-2-(4-(4-((4-(methylsulfonyl)piperazin-1-yl)methyl)phenoxy)piperidin-1-yl)pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1-(methylsulfonyl)-4-(4-(piperidin-4-yloxy)benzyl)piperazine ditrifluoroacetate

: 62802-42-0
2-chloro-5-fluoropyrimidine

: 1190979-31-7
5-fluoro-2-(4-(4-((4-(methylsulfonyl)piperazin-1-yl)methyl)phenoxy)piperidin-1-yl)pyrimidine

Guidance literature:: With potassium carbonate; In ISOPROPYLAMIDE; at 180 ℃; for 0.0833333h; Microwave irradiation;

Reference yield:

: 55276-43-2
4-methanesulfonylpiperazine

: 1190979-31-7
5-fluoro-2-(4-(4-((4-(methylsulfonyl)piperazin-1-yl)methyl)phenoxy)piperidin-1-yl)pyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic acid / 1,2-dichloro-ethane / 1 h / 90 °C

1.2: 2 h / 90 °C

2.1: 1 h / 20 °C

3.1: potassium carbonate / ISOPROPYLAMIDE / 0.08 h / 180 °C / Microwave irradiation

With potassium carbonate; acetic acid; In ISOPROPYLAMIDE; 1,2-dichloro-ethane;

Reference yield:

: 207798-38-7
4-(4-formylphenoxy)piperidine-1-carboxylic acid t-butyl ester

: 1190979-31-7
5-fluoro-2-(4-(4-((4-(methylsulfonyl)piperazin-1-yl)methyl)phenoxy)piperidin-1-yl)pyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic acid / 1,2-dichloro-ethane / 1 h / 90 °C

1.2: 2 h / 90 °C

2.1: 1 h / 20 °C

3.1: potassium carbonate / ISOPROPYLAMIDE / 0.08 h / 180 °C / Microwave irradiation

With potassium carbonate; acetic acid; In ISOPROPYLAMIDE; 1,2-dichloro-ethane;