N-tert-butyl 4-(4-((4-(methylsulfonyl)piperazin-1-yl)methyl)phenoxy)piperidine-1-carboxylate

Base Information

• Chemical Name: N-tert-butyl 4-(4-((4-(methylsulfonyl)piperazin-1-yl)methyl)phenoxy)piperidine-1-carboxylate
• CAS No.: 1190979-26-0
• Molecular Formula: C₂₂H₃₅N₃O₅S
• Molecular Weight: 453.603
• Mol file: 1190979-26-0.mol

Synonyms:N-tert-butyl 4-(4-((4-(methylsulfonyl)piperazin-1-yl)methyl)phenoxy)piperidine-1-carboxylate

Chemical Property of N-tert-butyl 4-(4-((4-(methylsulfonyl)piperazin-1-yl)methyl)phenoxy)piperidine-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-tert-butyl 4-(4-((4-(methylsulfonyl)piperazin-1-yl)methyl)phenoxy)piperidine-1-carboxylate

There total 3 articles about N-tert-butyl 4-(4-((4-(methylsulfonyl)piperazin-1-yl)methyl)phenoxy)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(4-formylphenoxy)piperidine-1-carboxylic acid t-butyl ester (207798-38-7) + 4-methanesulfonylpiperazine (55276-43-2) → N-tert-butyl 4-(4-((4-(methylsulfonyl)piperazin-1-yl)methyl)phenoxy)piperidine-1-carboxylate (1190979-26-0)

Guidance literature:

tert-butyl 4-(4-formylphenoxy)piperidine-1-carboxylate; 4-methanesulfonylpiperazine; With acetic acid; In 1,2-dichloro-ethane; at 90 ℃; for 1h;

With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 90 ℃; for 2h;

Reference yield:

t-butyl 4-hydroxy piperidine-1-carboxylate (109384-19-2) → N-tert-butyl 4-(4-((4-(methylsulfonyl)piperazin-1-yl)methyl)phenoxy)piperidine-1-carboxylate (1190979-26-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

2.1: caesium carbonate / N,N-dimethyl-formamide / 2 h / 80 °C

3.1: acetic acid / 1,2-dichloro-ethane / 1 h / 90 °C

3.2: 2 h / 90 °C

With caesium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; In dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

1-(tert-butoxycarbonyl)piperidin-4-yl methanesulfonate (141699-59-4) → N-tert-butyl 4-(4-((4-(methylsulfonyl)piperazin-1-yl)methyl)phenoxy)piperidine-1-carboxylate (1190979-26-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 2 h / 80 °C

2.1: acetic acid / 1,2-dichloro-ethane / 1 h / 90 °C

2.2: 2 h / 90 °C

With caesium carbonate; acetic acid; In 1,2-dichloro-ethane; N,N-dimethyl-formamide;

upstream raw materials:

4-(4-formylphenoxy)piperidine-1-carboxylic acid t-butyl ester

4-methanesulfonylpiperazine

t-butyl 4-hydroxy piperidine-1-carboxylate

1-(tert-butoxycarbonyl)piperidin-4-yl methanesulfonate

Downstream raw materials:

1-methylcyclopropyl 4-(4-((4-(methylsulfonyl)piperazin-1-yl)methyl)phenoxy)piperidine-1-carboxylate

5-fluoro-2-(4-(4-((4-(methylsulfonyl)piperazin-1-yl)methyl)phenoxy)piperidin-1-yl)pyrimidine