4-Methoxymethyl-2,3,5,6-tetrafluorobenzyl alcohol

Base Information

• Chemical Name: 4-Methoxymethyl-2,3,5,6-tetrafluorobenzyl alcohol
• CAS No.: 83282-91-1
• Molecular Formula: C9H8F4O2
• Molecular Weight: 224.155
• Hs Code.: 2942000000
• European Community (EC) Number: 846-804-2
• DSSTox Substance ID: DTXSID90457625
• Nikkaji Number: J1.797.221I
• Wikidata: Q72517070
• Mol file: 83282-91-1.mol

Synonyms:4-methoxymethyl-2,3,5,6-tetrafluorobenzyl alcohol

Chemical Property of 4-Methoxymethyl-2,3,5,6-tetrafluorobenzyl alcohol

Chemical Property:

• Vapor Pressure: 0.0928mmHg at 25°C
• Refractive Index: 1.464
• Boiling Point: 214.2 °C at 760 mmHg
• PKA: 12.85±0.10(Predicted)
• Flash Point: 106.8 °C
• PSA: 29.46000
• Density: 1.407 g/cm³
• LogP: 1.88170
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: Chloroform, Methanol
• XLogP3: 1.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 3
• Exact Mass: 224.04604214
• Heavy Atom Count: 15
• Complexity: 189

Purity/Quality:

99% ^*data from raw suppliers

[4-Methoxy-2- ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COCC1=C(C(=C(C(=C1F)F)CO)F)F
• Uses: 4-Methoxymethyl-2,3,5,6-tetrafluorobenzyl Alcohol is used as a reagent in the synthesis of Metofluthrin; a potent new synthetic pyrethroid with high vapor activity against mosquitos.

Technology Process of 4-Methoxymethyl-2,3,5,6-tetrafluorobenzyl alcohol

There total 10 articles about 4-Methoxymethyl-2,3,5,6-tetrafluorobenzyl alcohol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

2,3,5,6-tetrafluoro-1,4-benzenedimethanol (92339-07-6) + dimethyl sulfate (77-78-1) → 2,3,5,6-tetrafluoro-4-(methoxymethyl)benzyl alcohol (83282-91-1) + 1,4-bis(methoxymethyl)-2,3,5,6-tetrafluorobenzene

Guidance literature:

With potassium hydroxide; In water; toluene; at 50 - 60 ℃; for 4.5h; Heating / reflux;

Reference yield: 85.0%

4-methoxymethyl-2,3,5,6-tetrafluorotoluene (942435-98-5) → 2,3,5,6-tetrafluoro-4-(methoxymethyl)benzyl alcohol (83282-91-1)

Guidance literature:

With sulfuric acid; water; at 50 ℃; for 0.5h;

Reference yield: 75.7%

1,4-bis(methoxymethyl)-2,3,5,6-tetrafluorobenzene → 2,3,5,6-tetrafluoro-4-(methoxymethyl)benzyl alcohol (83282-91-1)

Guidance literature:

1,4-bis(methoxymethyl)-2,3,5,6-tetrafluorobenzene; With sulfuric acid; propionic acid; In water; at 140 - 145 ℃; for 10h;

With potassium carbonate; In water; at 90 - 95 ℃; for 12h;

With dimethyl sulfate; In water; toluene; at 40 - 45 ℃; for 2h; Temperature; Solvent; Reagent/catalyst;

upstream raw materials:

2,3,5,6-tetrafluoro-1,4-benzenedimethanol

dimethyl sulfate

tert-butyl methyl ether

4-methoxymethyl-2,3,5,6-tetrafluorotoluene

Downstream raw materials:

2,3,5,6-tetrafluoro-4-(methoxymethyl)benzyl 2,2-dimethyl-3-(2-methyl-1-propenyl)cyclopropanecarboxylate

metofluthrin

4-methoxymethyl-2,3,5,6-tetrafluorobenzyl (1R)-trans-3-[(E)-2-cyano-2-ethoxyethenyl]-2,2-dimethylcyclopropane carboxylate

4-methoxymethyl-2,3,5,6-tetrafluorobenzyl (1R)-trans-3-[(E)-2-cyano-2-methoxyethenyl]-2,2-dimethylcyclopropane carboxylate