4-methoxymethyl-2,3,5,6-tetrafluorobenzyl (1R)-trans-3-((Z)-2-cyano-1-propenyl)-2,2-dimethylcyclopropane carboxylate

Base Information

Chemical Name:4-methoxymethyl-2,3,5,6-tetrafluorobenzyl (1R)-trans-3-((Z)-2-cyano-1-propenyl)-2,2-dimethylcyclopropane carboxylate
CAS No.:1065124-65-3
Molecular Formula:C₁₉H₁₉F₄NO₃
Molecular Weight:385.358
Hs Code.:

Synonyms:4-methoxymethyl-2,3,5,6-tetrafluorobenzyl (1R)-trans-3-((Z)-2-cyano-1-propenyl)-2,2-dimethylcyclopropane carboxylate

Suppliers and Price of 4-methoxymethyl-2,3,5,6-tetrafluorobenzyl (1R)-trans-3-((Z)-2-cyano-1-propenyl)-2,2-dimethylcyclopropane carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 5 raw suppliers

Chemical Property of 4-methoxymethyl-2,3,5,6-tetrafluorobenzyl (1R)-trans-3-((Z)-2-cyano-1-propenyl)-2,2-dimethylcyclopropane carboxylate

Chemical Property:

Boiling Point:403.0±45.0 °C(Predicted)
Density:1.321±0.06 g/cm3(Predicted)

Purity/Quality:: 99.9% ^*data from raw suppliers

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Hazard Codes:

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Technology Process of 4-methoxymethyl-2,3,5,6-tetrafluorobenzyl (1R)-trans-3-((Z)-2-cyano-1-propenyl)-2,2-dimethylcyclopropane carboxylate

There total 3 articles about 4-methoxymethyl-2,3,5,6-tetrafluorobenzyl (1R)-trans-3-((Z)-2-cyano-1-propenyl)-2,2-dimethylcyclopropane carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 632-07-5
2-cyanopropanoic acid

: 443650-15-5
2,3,5,6-tetrafluoro-4-(methoxymethyl)benzyl (1R,3R)-2,2-dimethyl-3-formylcyclopropanecarboxylate

: 1065124-65-3
4-methoxymethyl-2,3,5,6-tetrafluorobenzyl (1R)-trans-3-((Z)-2-cyano-1-propenyl)-2,2-dimethylcyclopropane carboxylate

: 1246640-77-6
(2,3,5,6-tetrafluoro-4-methoxymethylbenzyl) (E)-(1R,3R)-3-(2-cyano-1-propenyl)-2,2-dimethylcyclopropanecarboxylate

Guidance literature:: With pyrrolidine; In N,N-dimethyl-formamide; toluene; at 80 ℃; for 6.5h;

Reference yield:

: 1170283-93-8
C₂₁H₂₁F₄NO₅

: 1065124-65-3
4-methoxymethyl-2,3,5,6-tetrafluorobenzyl (1R)-trans-3-((Z)-2-cyano-1-propenyl)-2,2-dimethylcyclopropane carboxylate

: 1246640-77-6
(2,3,5,6-tetrafluoro-4-methoxymethylbenzyl) (E)-(1R,3R)-3-(2-cyano-1-propenyl)-2,2-dimethylcyclopropanecarboxylate

Guidance literature:: C₂₁H₂₁F₄NO₅; With sodium tetrahydroborate; In N,N-dimethyl-formamide; Inert atmosphere; Cooling with ice;

With hydrogenchloride; water; In N,N-dimethyl-formamide; Inert atmosphere;

Reference yield:

: 83282-91-1
2,3,5,6-tetrafluoro-4-(methoxymethyl)benzyl alcohol

: 1052115-15-7
(1R)-trans-3-(2-cyano-1-propenyl)-2,2-dimethylcyclopropanecarboxylic acid

: 1065124-65-3
4-methoxymethyl-2,3,5,6-tetrafluorobenzyl (1R)-trans-3-((Z)-2-cyano-1-propenyl)-2,2-dimethylcyclopropane carboxylate

: 1246640-77-6
(2,3,5,6-tetrafluoro-4-methoxymethylbenzyl) (E)-(1R,3R)-3-(2-cyano-1-propenyl)-2,2-dimethylcyclopropanecarboxylate

Guidance literature:: 2,3,5,6-tetrafluoro-4-(methoxymethyl)benzyl alcohol; With zirconium(IV) tetraisopropoxide; In isopropyl alcohol; xylene; Reflux;

(1R)-trans-3-(2-cyano-1-propenyl)-2,2-dimethylcyclopropanecarboxylic acid; In isopropyl alcohol; xylene; at 80 ℃; Product distribution / selectivity; Reflux;