(3R,4S)-3-(Dimethyl-phenyl-silanyloxy)-1-(4-methoxy-phenyl)-4-phenyl-azetidin-2-one

Base Information

• Chemical Name: (3R,4S)-3-(Dimethyl-phenyl-silanyloxy)-1-(4-methoxy-phenyl)-4-phenyl-azetidin-2-one
• CAS No.: 209110-50-9
• Molecular Formula: C₂₄H₂₅NO₃Si
• Molecular Weight: 403.553

Synonyms:(3R,4S)-3-(Dimethyl-phenyl-silanyloxy)-1-(4-methoxy-phenyl)-4-phenyl-azetidin-2-one

Chemical Property of (3R,4S)-3-(Dimethyl-phenyl-silanyloxy)-1-(4-methoxy-phenyl)-4-phenyl-azetidin-2-one

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

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Technology Process of (3R,4S)-3-(Dimethyl-phenyl-silanyloxy)-1-(4-methoxy-phenyl)-4-phenyl-azetidin-2-one

There total 1 articles about (3R,4S)-3-(Dimethyl-phenyl-silanyloxy)-1-(4-methoxy-phenyl)-4-phenyl-azetidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(4-Methoxyphenyl)-3-triisopropylsilyloxy-4-phenyl-2-azetidinone (144465-78-1) + phenyldimethylsilyl chloride (768-33-2) → (3R,4S)-3-(Dimethyl-phenyl-silanyloxy)-1-(4-methoxy-phenyl)-4-phenyl-azetidin-2-one (209110-50-9)

Guidance literature:

With piperidine; dmap; hydrogen fluoride; triethylamine; Yield given. Multistep reaction; 2.) CH₂Cl₂, RT;

DOI:10.1016/S0040-4039(98)00643-1

Reference yield: 72.0%

allyl bromide (106-95-6) + (3R,4S)-3-(Dimethyl-phenyl-silanyloxy)-1-(4-methoxy-phenyl)-4-phenyl-azetidin-2-one (209110-50-9) → (3R,4S)-3-Allyl-3-(dimethyl-phenyl-silanyloxy)-1-(4-methoxy-phenyl)-4-phenyl-azetidin-2-one (209110-58-7)

Guidance literature:

With lithium diisopropyl amide; In tetrahydrofuran; at -78 - -10 ℃;

DOI:10.1016/S0040-4039(98)00643-1

Reference yield: 56.0%

(3R,4S)-3-(Dimethyl-phenyl-silanyloxy)-1-(4-methoxy-phenyl)-4-phenyl-azetidin-2-one (209110-50-9) + methyl iodide (74-88-4) → (3R,4S)-3-(Dimethyl-phenyl-silanyloxy)-1-(4-methoxy-phenyl)-3-methyl-4-phenyl-azetidin-2-one (209110-55-4)

Guidance literature:

With lithium diisopropyl amide; In tetrahydrofuran; at -78 - -10 ℃;

DOI:10.1016/S0040-4039(98)00643-1

upstream raw materials:

1-(4-Methoxyphenyl)-3-triisopropylsilyloxy-4-phenyl-2-azetidinone

phenyldimethylsilyl chloride

Downstream raw materials:

(3R,4S)-3-Allyl-3-(dimethyl-phenyl-silanyloxy)-1-(4-methoxy-phenyl)-4-phenyl-azetidin-2-one

(3R,4S)-3-(Dimethyl-phenyl-silanyloxy)-1-(4-methoxy-phenyl)-3-methyl-4-phenyl-azetidin-2-one

(2R,3S)-3-(tert-butoxycarbonylamino)-2-hydroxy-2-methyl-3-phenylpropionic acid methyl ester

(3R,4S)-3-hydroxy-3-methyl-4-phenyl-β-lactam

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