(2R,3S)-3-(tert-butoxycarbonylamino)-2-hydroxy-2-methyl-3-phenylpropionic acid methyl ester

Base Information

Chemical Name:(2R,3S)-3-(tert-butoxycarbonylamino)-2-hydroxy-2-methyl-3-phenylpropionic acid methyl ester
CAS No.:168416-37-3
Molecular Formula:C₁₆H₂₃NO₅
Molecular Weight:309.362
Hs Code.:

Synonyms:(2R,3S)-3-(tert-butoxycarbonylamino)-2-hydroxy-2-methyl-3-phenylpropionic acid methyl ester

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Chemical Property of (2R,3S)-3-(tert-butoxycarbonylamino)-2-hydroxy-2-methyl-3-phenylpropionic acid methyl ester

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Technology Process of (2R,3S)-3-(tert-butoxycarbonylamino)-2-hydroxy-2-methyl-3-phenylpropionic acid methyl ester

There total 14 articles about (2R,3S)-3-(tert-butoxycarbonylamino)-2-hydroxy-2-methyl-3-phenylpropionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 357615-92-0
(2R,3S)-3-azido-2-hydroxy-2-methyl-3-phenylpropionic acid methyl ester

: 168416-37-3
(2R,3S)-3-(tert-butoxycarbonylamino)-2-hydroxy-2-methyl-3-phenylpropionic acid methyl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate; for 48h;
DOI:10.1016/S0957-4166(01)00173-2

Reference yield: 50.0%

: 67-56-1
methanol

: 209110-70-3
(3R,4S)-3-(Dimethyl-phenyl-silanyloxy)-3-methyl-2-oxo-4-phenyl-azetidine-1-carboxylic acid tert-butyl ester

: 168416-37-3
(2R,3S)-3-(tert-butoxycarbonylamino)-2-hydroxy-2-methyl-3-phenylpropionic acid methyl ester

Guidance literature:: With dmap; triethylamine;
DOI:10.1016/S0040-4039(98)00643-1

Reference yield:

: 313673-02-8
(2S,5R,1'R)-2-(tert-Butyl)-5-(1'-hydroxy-1'-phenylmethyl)-2,5-diethyl-1,3-dioxolan-4-one

: 168416-37-3
(2R,3S)-3-(tert-butoxycarbonylamino)-2-hydroxy-2-methyl-3-phenylpropionic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / di-iso-propylazodicarboxylate; ZnN₆*2Py; PPh₃ / toluene / 3 h / 25 °C / sonication

2: 85 percent / methanol / 0.75 h / 60 °C

3: 80 percent / H₂ / Pd-C / ethyl acetate / 48 h

With Zn(N₃)2/bis-pyridine complex; di-isopropyl azodicarboxylate; hydrogen; triphenylphosphine; palladium on activated charcoal; In methanol; ethyl acetate; toluene;
DOI:10.1016/S0957-4166(01)00173-2