2-(tert-butyl-dimethyl-silanyloxymethyl)-5-[2-methyl-4-(methyl-phenyl-amino)-pyrazolo[1,5-a][1,3,5]triazin-8-yl]-dihydro-furan-3-one

Base Information

Chemical Name:2-(tert-butyl-dimethyl-silanyloxymethyl)-5-[2-methyl-4-(methyl-phenyl-amino)-pyrazolo[1,5-a][1,3,5]triazin-8-yl]-dihydro-furan-3-one
CAS No.:906000-94-0
Molecular Formula:C₂₄H₃₃N₅O₃Si
Molecular Weight:467.643
Hs Code.:

2-(<i>tert</i>-butyl-dimethyl-silanyloxymethyl)-5-[2-methyl-4-(methyl-phenyl-amino)-pyrazolo[1,5-<i>a</i>][1,3,5]triazin-8-yl]-dihydro-furan-3-one

Synonyms:2-(tert-butyl-dimethyl-silanyloxymethyl)-5-[2-methyl-4-(methyl-phenyl-amino)-pyrazolo[1,5-a][1,3,5]triazin-8-yl]-dihydro-furan-3-one

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Chemical Property of 2-(tert-butyl-dimethyl-silanyloxymethyl)-5-[2-methyl-4-(methyl-phenyl-amino)-pyrazolo[1,5-a][1,3,5]triazin-8-yl]-dihydro-furan-3-one

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Technology Process of 2-(tert-butyl-dimethyl-silanyloxymethyl)-5-[2-methyl-4-(methyl-phenyl-amino)-pyrazolo[1,5-a][1,3,5]triazin-8-yl]-dihydro-furan-3-one

There total 1 articles about 2-(tert-butyl-dimethyl-silanyloxymethyl)-5-[2-methyl-4-(methyl-phenyl-amino)-pyrazolo[1,5-a][1,3,5]triazin-8-yl]-dihydro-furan-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 476468-46-9
2-methyl-4-(N-methyl-N-phenylamino)-8-(β-D-glycero-pentofuran-3'-ulose-1'-yl)pyrazolo[1,5-a]-1,3,5-triazine

: 906000-94-0
2-(tert-butyl-dimethyl-silanyloxymethyl)-5-[2-methyl-4-(methyl-phenyl-amino)-pyrazolo[1,5-a][1,3,5]triazin-8-yl]-dihydro-furan-3-one

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 35 ℃; for 16h;
DOI:10.1016/j.tetlet.2006.05.077

Reference yield: 90.0%

: 906000-94-0
2-(tert-butyl-dimethyl-silanyloxymethyl)-5-[2-methyl-4-(methyl-phenyl-amino)-pyrazolo[1,5-a][1,3,5]triazin-8-yl]-dihydro-furan-3-one

: 1099-45-2
ethyl (triphenylphosphoranylidene)acetate

: 906000-96-2
{2-(tert-butyl-dimethyl-silanyloxymethyl)-5-[2-methyl-4-(methyl-phenyl-amino)-pyrazolo[1,5-a][1,3,5]triazin-8-yl]-dihydro-furan-3-ylidene}-acetic acid ethyl ester

Guidance literature:: In toluene; for 18h; Heating;
DOI:10.1016/j.tetlet.2006.05.077

Reference yield:

: 906000-94-0
2-(tert-butyl-dimethyl-silanyloxymethyl)-5-[2-methyl-4-(methyl-phenyl-amino)-pyrazolo[1,5-a][1,3,5]triazin-8-yl]-dihydro-furan-3-one

: 906001-05-6
[(2S,3R,5R)-2-(Bis-benzyloxy-phosphoryloxymethyl)-5-(2-methyl-4-methylamino-pyrazolo[1,5-a][1,3,5]triazin-8-yl)-tetrahydro-furan-3-yl]-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 90 percent / toluene / 18 h / Heating

2: 62 percent / H₂ / Pd/C / methanol / 24 h / 20 °C / 3102.89 Torr

3: 98 percent / MeNH₂ / ethanol / 16 h / 100 °C

4: 86 percent / TBAF / tetrahydrofuran / 1 h / 20 °C

5: 87 percent / tBuOK / tetrahydrofuran / 0.5 h / -40 °C

With potassium tert-butylate; tetrabutyl ammonium fluoride; hydrogen; methylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; toluene; 1: Wittig reaction;
DOI:10.1016/j.tetlet.2006.05.077