6-hydroxymethyl-4-methyl-2-propyl-1-[2'-(1-triphenylmethyl-1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-benzimidazole

Base Information

Chemical Name:6-hydroxymethyl-4-methyl-2-propyl-1-[2'-(1-triphenylmethyl-1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-benzimidazole
CAS No.:1046423-49-7
Molecular Formula:C₄₅H₄₀N₆O
Molecular Weight:680.852
Hs Code.:

Synonyms:6-hydroxymethyl-4-methyl-2-propyl-1-[2'-(1-triphenylmethyl-1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-benzimidazole

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Chemical Property of 6-hydroxymethyl-4-methyl-2-propyl-1-[2'-(1-triphenylmethyl-1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-benzimidazole

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Technology Process of 6-hydroxymethyl-4-methyl-2-propyl-1-[2'-(1-triphenylmethyl-1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-benzimidazole

There total 1 articles about 6-hydroxymethyl-4-methyl-2-propyl-1-[2'-(1-triphenylmethyl-1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-benzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1046423-45-3
4-methyl-2-propyl-1-[2'-(1-triphenylmethyl-1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-benzimidazole-6-carboxylic acid methyl ester

: 1046423-49-7
6-hydroxymethyl-4-methyl-2-propyl-1-[2'-(1-triphenylmethyl-1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-benzimidazole

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃;

Reference yield:

: 299176-17-3
N-(2-nitro-5-chlorophenyl)-N-methylcarbamic acid t-butyl ester

: 1046423-49-7
6-hydroxymethyl-4-methyl-2-propyl-1-[2'-(1-triphenylmethyl-1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-benzimidazole

: 1350439-63-2
6-(3-(N-t-butoxycarbonyl-N-methylamino)-4-nitrophenoxymethyl)-4-methyl-2-propyl-1-[2'-(1-triphenylmethyl-1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-benzimidazole

Guidance literature:: 6-hydroxymethyl-4-methyl-2-propyl-1-[2'-(1-triphenylmethyl-1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-benzimidazole; With sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 1.71667h; Cooling with ice;

N-(2-nitro-5-chlorophenyl)-N-methylcarbamic acid t-butyl ester; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil; at 20 ℃;

Reference yield:

: 1046423-49-7
6-hydroxymethyl-4-methyl-2-propyl-1-[2'-(1-triphenylmethyl-1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-benzimidazole

: 6-(4-amino-3-methylaminophenoxymethyl)-4-methyl-2-propyl-1-[2'-(1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-benzimidazole hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide; mineral oil / 1.72 h / 20 °C / Cooling with ice

1.2: 20 °C

2.1: iron; hydrogenchloride / tetrahydrofuran; ethanol; methanol; water / 4 h / 20 °C

With hydrogenchloride; iron; sodium hydride; In tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide; mineral oil;